Research article summary (published 30 Dec 1989):

Behavioral and genetic interrelationships between locomotor activity and brain biogenic amines.

Full Abstract

1. Spontaneous locomotor activity of four mouse strains, the albino ICR, BALB/C, the black C57 BL/6 and the brown CDF-I, was studied in conjunction with whole brain content of select biogenic amines and major metabolites. The ICR and C57BL/6 mice scored the highest and lowest motility among the strains studied, respectively. 2. The ICR mice motility were the most sensitive to experimental stress among the mouse strains evaluated. 3. Brain dopamine concentrations were greater in ICR and CDF-I mice than the other two mouse strains. This is compared to high serotonin and 5-hydroxyindole acetic acid levels determined in C57BL/6. 4. A relationship between the ICR mouse strain with a high motility and the ratios of brain dopamine:homovanillic acid and between serotonin:5-hydroxyindole acetic acid was established. 5. An inverse relationship between ICR mice motility and the ratio of metanephrine and normetanephrine:3-methoxy-4-hydroxyphenylglycol (MHPG) was determined. 6. It is concluded that genetic predisposition may account for a relationship between motor activity and brain biogenic amines which may give insight into the susceptibility of different patients to the development of certain extrapyramidal diseases.

Author information

Author/s: Messiha, F S (FS); Martin, W J (WJ); Bucher, K D (KD);

Affiliation: Department of Pharmacology, School of Medicine, University of North Dakota, Grand Forks 58203.

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: General pharmacology (Gen Pharmacol), published in ENGLAND. (Language: eng)

Reference: 1990-; vol 21 (issue 4) : pp 459-64

Dates: Created 1990/09/12; Completed 1990/09/12; Revised 2006/11/15;

PMID: 1696231, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Behavior, Animal - physiology Biogenic Amines - metabolism Brain Chemistry Chromatography, High Pressure Liquid Dopamine - metabolism Epinephrine - metabolism Hydroxyindoleacetic Acid - metabolism Male Methoxyhydroxyphenylglycol - metabolism

Methoxyhydroxyphenylglycol - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred ICR Mice, Inbred Strains Motor Activity - genetics; physiology Norepinephrine - metabolism Serotonin - metabolism Species Specificity

Associated Chemicals: Biogenic Amines (0) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; Epinephrine (51-43-4) ; Dopamine (51-61-6) ; Methoxyhydroxyphenylglycol (534-82-7) ; Hydroxyindoleacetic Acid (54-16-0)

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