Histopathological findings of new in-stent lesions developed beyond five years.

Full Abstract

We analyzed 14 cases of new lesions inside implanted bare-metal stents. In every case, there was no angiographic restenosis within 3 years, but a new lesion was observed inside a stented segment at long-term follow-up (>5 years). Fourteen cases were evaluated: 9 with Wiktor stents, 2 with Palmaz-Schatz stents, and 3 with ACS Multilink stents. The interval from stent implantation to follow-up angiography was 63-147 months (89 +/- 23). Thirteen lesions were treated by percutaneous coronary intervention (PCI) and stenotic tissue was obtained by directional coronary atherectomy (DCA) in 10 cases. All retrieved samples were composed of newly developed atherosclerosis facing the healed neointimal layer, and four samples showed histopathological findings of acute coronary syndrome. Stent struts were retrieved in four cases and no inflammation was observed surrounding them. Qualitative and quantitative analysis of stent struts was performed in two cases that showed no metal corrosion. These findings suggest that new atherosclerotic progression occurred inside the implanted stent without peristrut inflammation.

Author information

Author/s: Hasegawa, Katsuyuki (K); Tamai, Hideo (H); Kyo, Eisho (E); Kosuga, Kunihiko (K); Ikeguchi, Shigeru (S); Hata, Tatsuhiko (T); Okada, Masaharu (M); Fujita, Shinya (S); Tsuji, Takafumi (T); Takeda, Shinsaku (S); Fukuhara, Rei (R); Kikuta, Yuetsu (Y); Motohara, Seiichiro (S); Ono, Kazuo (K); Takeuchi, Eiji (E);

Affiliation: Department of Cardiology, Shiga Medical Center for Adults, Shiga, Japan.

Journal and publication information

Publication Type: Case Reports; Journal Article

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (Catheter Cardiovasc Interv), published in United States. (Language: eng)

Reference: 2006-Oct; vol 68 (issue 4) : pp 554-8

Dates: Created 2006/10/02; Completed 2006/12/21; Revised 2008/02/07;

PMID: 16969849, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Catheter Cardiovasc Interv. 2006 Oct;68(4):559-60. (PMID: 16969850)

CommentIn: Catheter Cardiovasc Interv. 2007 Dec 1;70(7):1051; author reply 1052. (PMID: 18044789)

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