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| Research article summary (published 12 Sep 2006): |
Exhaled nasal nitric oxide output is reduced in humans at night during the sleep period.
Full Abstract
The physiologic function of nasal nitric oxide (NO) release is unknown. In prior experiments, topical NG-nitro-L-arginine methyl ester (L-NAME) on nasal mucosa reduced exhaled nasal NO output and caused daytime sleepiness. We hypothesized that nasal NO output is reduced at night during the sleep period. We measured exhaled nasal NO concentration and minute ventilation and calculated nasal NO output in humans over 24 h. Daytime awake NO output was greater than NO output at night during sleep or transient wakefulness. Exhaled NO concentration decreased during sleep along with minute ventilation. A daytime voluntary reduction in minute ventilation also decreased nasal NO output but exhaled NO concentration increased. Nasal NO output was not changed by body position. We conclude that exhaled nasal NO output is decreased at night due to decreased mass flow of NO into nasal air in addition to decreased minute ventilation. Our findings suggest a role of nasal NO in sleep or in the physiologic processes accompanying sleep.
Author information
Author/s: O'Hearn, Daniel J (DJ); Giraud, George D (GD); Sippel, Jeffrey M (JM); Edwards, Chad (C); Chan, Benjamin (B); Holden, William E (WE);
Affiliation: Medical Service, Portland Veterans Administration Medical Center and Oregon Health and Science University, Portland, OR 97201, USA. ohearnd(-atsign-)ohsu.edu
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Respiratory physiology & neurobiology (Respir Physiol Neurobiol), published in Netherlands. (Language: eng)
Reference: 2007-Apr; vol 156 (issue 1) : pp 94-101
Dates: Created 2007/02/16; Completed 2007/05/01;
PMID: 16978930, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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