Research article summary (published 30 Aug 2006):

HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.

Full Abstract

BACKGROUND: A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS). METHODS: We have genotyped the HLA-B alleles in 56 Caucasian patients with varying severities of CBZ hypersensitivity and 43 controls on CBZ without adverse effects. RESULTS: None of our patients (including two with blistering skin rashes) were positive for the HLA-B*1502 allele. HLA-B*0702 allele may protect against severe CBZ hypersensitivity but warrants further study. Of secondary interest, the correlation between HLA-B*0801 and HLA-DR3, DQ2 and TNF -308 alleles (on the ancestral haplotype 8.1) is consistent with our previous findings. CONCLUSION: HLA-B*1502 does not seem to be a marker for all forms of CBZ-induced hypersensitivity in a Caucasian population.

Author information

Author/s: Alfirevic, Ana (A); Jorgensen, Andrea L (AL); Williamson, Paula R (PR); Chadwick, David W (DW); Park, B Kevin (BK); Pirmohamed, Munir (M);

Affiliation: Department of Pharmacology & Therapeutics, The University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.

Journal and publication information

Publication Type: Journal Article

Journal: Pharmacogenomics (Pharmacogenomics), published in England. (Language: eng)

Reference: 2006-Sep; vol 7 (issue 6) : pp 813-8

Dates: Created 2006/09/19; Completed 2006/11/08;

PMID: 16981842, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alleles Asian Continental Ancestry Group - genetics Carbamazepine - adverse effects Case-Control Studies Drug Hypersensitivity - genetics; immunology European Continental Ancestry Group - genetics Gene Frequency

Genetic Markers Great Britain HLA-B Antigens - genetics HLA-DQ Antigens - genetics HLA-DR3 Antigen - genetics Humans Toxicogenetics

Associated Chemicals: Genetic Markers (0) ; HLA-B Antigens (0) ; HLA-B*0702 (0) ; HLA-B*0801 antigen (0) ; HLA-B*1502, human (0) ; HLA-DQ Antigens (0) ; HLA-DQ2 antigen, human (0) ; HLA-DR3 Antigen (0) ; Carbamazepine (298-46-4)

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