Cord blood dendritic cell subsets in African newborns exposed to Plasmodium falciparum in utero.

Full Abstract

Placental Plasmodium falciparum infection affects birth outcomes and sensitizes fetal lymphocytes to parasite antigens. We assessed the influence of maternal P. falciparum infection on fetal myeloid dendritic cells (mDC) and plasmacytoid dendritic cells (pDC), analyzing the cord blood of offspring of Gabonese mothers with different infection histories. Cord blood from newborns of mothers with malarial infection at delivery had significantly more mDC than that from nonexposed newborns (P = 0.028) but mDC and pDC HLA-DR expression was unrelated to maternal infection history. Independently of these findings, cord blood mDC and pDC numbers declined significantly as a function of increasing maternal age (P = 0.029 and P = 0.033, respectively). The inducible antigen-specific interleukin-10-producing regulatory-type T-cell population that we have previously detected in cord blood of newborns with prolonged in utero exposure to P. falciparum may directly reflect the altered DC numbers in such neonates, while the maintenance of cord blood DC HLA-DR expression contrasts with that of DC from P. falciparum malaria patients.

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Author information

Author/s: Breitling, Lutz P (LP); Fendel, Rolf (R); Mordmueller, Benjamin (B); Adegnika, Ayola A (AA); Kremsner, Peter G (PG); Luty, Adrian J F (AJ);

Affiliation: Medical Parasitology-268, Department of Medical Microbiology, MMB-NCMLS, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Infection and immunity (Infect Immun), published in United States. (Language: eng)

Reference: 2006-Oct; vol 74 (issue 10) : pp 5725-9

Dates: Created 2006/09/21; Completed 2006/11/28; Revised 2008/11/21;

PMID: 16988249, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Dendritic Cells - immunology
Female
Fetal Blood - cytology; immunology; parasitology
HLA-DR Antigens - analysis
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical

Lectins, C-Type - analysis
Malaria, Falciparum - immunology; transmission
Membrane Glycoproteins - analysis
Plasmodium falciparum
Pregnancy
Pregnancy Complications, Parasitic - immunology
Receptors, Immunologic - analysis
Uterus - immunology; parasitology

Associated Chemicals: CLEC4C protein, human (0) ; HLA-DR Antigens (0) ; Lectins, C-Type (0) ; Membrane Glycoproteins (0) ; Receptors, Immunologic (0)

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