Research article summary (published Oct 2006):

Relationship between limbic and cortical 5-HT neurotransmission and acquisition and reversal learning in a go/no-go task in rats.

Full Abstract

RATIONALE: Specific brain structures have been suggested to be involved in impulsive responding assessed by a variety of operant tasks. Central serotonin (5-HT) function has also been widely implicated in impulsivity; however, little research has addressed the regional aspect of 5-HT roles in different impulsive indices of task performance. OBJECTIVE: We analyzed the relationships between acquisition and reversal learning in a go/no-go task as different behavioral measures of impulsivity and focal concentrations of 5-HT and its metabolites in the brain. MATERIALS AND METHODS: Rats administered with parachloroamphetamine (PCA) and vehicle were tested in both acquisition and reversal phases in a go/no-go visual discrimination task. Neurochemical analysis was performed to determine 5-HT concentrations in micropunched brain tissues. RESULTS: PCA administration induced regionally 5-HT depletion in the brain and impaired learning performance in both tests. For both tests, significant negative correlations between learning performance and 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) concentrations were observed in the medial prefrontal cortex (mPFC) and amygdala (Amyg). In contrast, significant negative correlations between learning performance and 5-HT and 5-HIAA concentrations were observed for the orbitofrontal cortex (OFC) exclusively in the reversal learning phase. CONCLUSIONS: The present data indicate that 5-HT neurotransmission to the mPFC and Amyg is involved in inhibitory control over responses to discriminated stimuli associated with the go/no-go paradigm common to both tests. In contrast, 5-HT neurotransmission to the OFC is especially involved in additional processes associated with reversal learning.

Author information

Author/s: Masaki, Daiki (D); Yokoyama, Chihiro (C); Kinoshita, Seijiro (S); Tsuchida, Hideto (H); Nakatomi, Yasuhito (Y); Yoshimoto, Kanji (K); Fukui, Kenji (K);

Affiliation: Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Psychopharmacology (Psychopharmacology (Berl)), published in Germany. (Language: eng)

Reference: 2006-Dec; vol 189 (issue 2) : pp 249-58

Dates: Created 2006/11/06; Completed 2007/02/05;

PMID: 17016708, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

3,4-Dihydroxyphenylacetic Acid - metabolism Amygdala - drug effects; metabolism Animals Brain - drug effects; metabolism Cerebral Cortex - drug effects; metabolism; physiology Conditioning, Operant - drug effects; physiology Discrimination Learning - drug effects; physiology Dopamine - metabolism Feeding Behavior - drug effects Hippocampus - drug effects; metabolism Hydroxyindoleacetic Acid - metabolism Limbic System - drug effects; metabolism; physiology

Male Motor Activity - drug effects Nucleus Accumbens - drug effects; metabolism Prefrontal Cortex - drug effects; metabolism Rats Rats, Wistar Reversal Learning - drug effects; physiology Serotonin - metabolism; physiology Serotonin Antagonists - pharmacology Stress, Psychological - psychology Synaptic Transmission - drug effects; physiology p-Chloroamphetamine - pharmacology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Serotonin Antagonists (0) ; 3,4-Dihydroxyphenylacetic Acid (102-32-9) ; Serotonin (50-67-9) ; Dopamine (51-61-6) ; Hydroxyindoleacetic Acid (54-16-0) ; p-Chloroamphetamine (64-12-0)

Related articles

These are the most related articles currently in our database:

• Serotonergic lesions alter cocaine-induced locomotor behavior and stress-activation of the mesocorticolimbic dopamine system. 29 Jun 1996
• Differential effects of d-fenfluramine and p-chloroamphetamine on H75/12-induced depletion of 5-hydroxytryptamine and dopamine in the rat brain. 30 Dec 1990
• Effects of repeated cocaine on medial prefrontal cortical GABAB receptor modulation of neurotransmission in the mesocorticolimbic dopamine system. 30 Jul 2004
• Limbic and prefrontal contributions to somesthetic learning in monkeys. 31 Aug 1977
• Lesions of the prelimbic-infralimbic cortices in rats do not disrupt response selection processes but induce delay-dependent deficits: evidence for a role in working memory? 29 Sep 1999
• Interaction between thyrotropin-releasing hormone and the mesolimbic dopamine system. 30 Dec 1986
• Long-lasting enhancement of metabotropic excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of deep prepiriform cortical kindled rats. 6 Jan 1992
• Changes in locomotion and dopamine neurotransmission following amphetamine, haloperidol, and exposure to novel environmental stimuli. 30 Dec 1989
• Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the rat. 7 Feb 2007
• Serial reversal learning and acute tryptophan depletion. 18 Jul 2007

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a larger map of 100+ related articles.