Research article summary (published 29 Sep 2006):

Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer.

Full Abstract

To develop an intelligent sensor-effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4-6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted diagnostic and therapeutic applications in medicine.

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Author information

Author/s: Broz, Pavel (P); Driamov, Sergey (S); Ziegler, Joerg (J); Ben-Haim, Nadav (N); Marsch, Stephan (S); Meier, Wolfgang (W); Hunziker, Patrick (P);

Affiliation: Medical Intensive Care Unit, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Nano letters (Nano Lett), published in United States. (Language: eng)

Reference: 2006-Oct; vol 6 (issue 10) : pp 2349-53

Dates: Created 2006/10/12; Completed 2006/11/20;

PMID: 17034109, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Bioreactors Biosensing Techniques - instrumentation Equipment Design Equipment Failure Analysis

Hydrogen-Ion Concentration Nanotechnology - instrumentation; methods Polymers - chemistry Porins - chemistry

Associated Chemicals: OmpF protein (0) ; Polymers (0) ; Porins (0)

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