Nitric oxide, endothelin-1, and superoxide production in arterial bypass grafts.

Full Abstract

In this study, basal and thrombin-stimulated release of nitric oxide and endothelin-1 in the internal mammary artery and the radial artery were measured, together with superoxide radicals generated after anoxia and reoxygenation. Arterial segments were obtained from patients undergoing coronary bypass operations. Quantification of nitric oxide was performed by measuring the stable oxidation products of nitric oxide. Endothelin levels were measured by an enzyme immunoassay kit, and the superoxides were measured by lucigenin-enhanced chemiluminescence. Basal and stimulated release of nitric oxide from the internal mammary artery is significantly higher than that in the radial artery. On the other hand, basal release of endothelin-1 is less in the internal mammary artery than in the radial artery, but similar after stimulation. In our study, the quantity of superoxide radicals produced by the internal mammary artery was greater than that produced by the radial artery. Our results show that there are differences between these 2 arteries in regard to production of nitric oxide, endothelin-1, and superoxide radicals. These differences may have a role in the process of atherogenesis and may contribute to long-term patency of arterial bypass grafts. These results may also explain the mechanism of radial artery graft spasm in coronary artery surgery and may constitute a basis for future pharmacological and clinical improvements for successful surgical application.

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Author information

Author/s: Aksungar, Fehime Benli (FB); Moini, Hadi (H); Unal, Mehmet (M); Yilmaz, Oguz (O); Sonmez, Bingur (B); Bilsel, Serpil (S);

Affiliation: Department of Biochemistry, University of Maltepe, 34844 Istanbul, Turkey.

Journal and publication information

Publication Type: Journal Article

Journal: Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital (Tex Heart Inst J), published in United States. (Language: eng)

Reference: 2006-; vol 33 (issue 3) : pp 294-9

Dates: Created 2006/10/16; Completed 2006/11/07; Revised 2008/11/20;

PMID: 17041684, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Atherosclerosis - metabolism
Coronary Artery Bypass
Coronary Vasospasm - physiopathology
Endothelin-1 - biosynthesis
Humans
Luminescence

Luminescence
Mammary Arteries - metabolism; transplantation
Nitric Oxide - biosynthesis
Radial Artery - metabolism; transplantation
Superoxides - metabolism
Vascular Patency - physiology

Associated Chemicals: Endothelin-1 (0) ; Nitric Oxide (10102-43-9) ; Superoxides (11062-77-4)

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