Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples.

Full Abstract

Brain-derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement of BDNF in attention-deficit hyperactivity disorder (ADHD). This study investigated the role of two common BDNF variants (Val66Met, C270T) in two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212). We found evidence of increased transmission of the C allele of the C270T in Taiwanese samples (TDT:
chi(2) = 6.78, P = 0.009) and the two samples pooled together (TDT:
chi(2) = 7.24, P = 0.007). No association was found between the Val66Met polymorphism and ADHD in either of the two populations. Analysis of haplotypes demonstrated a significant decreased transmission of haplotypes containing the Val66 allele and the 270T allele in the Taiwanese samples (TDT:
chi(2) = 4.57, P = 0.032) and the pooled sample set (TDT:
chi(2) = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD.

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Author information

Author/s: Xu, Xiaohui (X); Mill, Jonathan (J); Zhou, Kaixin (K); Brookes, Keeley (K); Chen, Chih-Ken (CK); Asherson, Philip (P);

Affiliation: MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK. x.xu(-atsign-)iop.kcl.ac.uk

Grants: (Agency:Wellcome Trust)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet), published in United States. (Language: eng)

Reference: 2007-Jan; vol 144B (issue 1) : pp 83-6

Dates: Created 2006/12/27; Completed 2007/02/27; Revised 2008/05/21;

PMID: 17044097, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Alleles
Amino Acid Substitution
Attention Deficit Disorder with Hyperactivity - genetics; metabolism
Brain-Derived Neurotrophic Factor - genetics
Child
Child, Preschool
Female

Associated Chemicals: Brain-Derived Neurotrophic Factor (0)

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