Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury.

Full Abstract

Spinal cord injury (SCI) pain exhibits many symptoms associated with peripheral neuropathic pain, including increased tactile hypersensitivity. One novel approach to ameliorate SCI pain is the use of cannabinoid (CB) ligands. The current study evaluated the efficacy of the nonselective CB receptor agonist WIN 55,212-2 on tactile hypersensitivity in rats following a brief compression to the thoracic spinal cord. The withdrawal thresholds of the hind paws following SCI were significantly decreased, indicating tactile hypersensitivity. Systemic injection of WIN 55,212-2 increased withdrawal thresholds in a dose-dependent manner. Pretreatment with the CB(1) receptor subtype-selective antagonist AM 251 completely abolished the antinociceptive effect of WIN 55,212-2 whereas pretreatment with the CB(2) receptor subtype-selective antagonist AM 630 did not alter the antinociceptive effect of WIN 55,212-2. These data indicate that a CB(1)-selective agonist may be novel therapeutic treatment for clinical SCI pain.

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Author information

Author/s: Hama, Aldric (A); Sagen, Jacqueline (J);

Affiliation: University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace (R-48), Miami, FL 33136, USA. ahama(-atsign-)med.miami.edu

Grants: DA10546 (Agency:NIDA NIH HHS) ; R01 DA010546-06 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Experimental neurology (Exp Neurol), published in United States. (Language: eng)

Reference: 2007-Mar; vol 204 (issue 1) : pp 454-7

Dates: Created 2007/03/06; Completed 2007/05/10; Revised 2008/11/20;

PMID: 17045264, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analgesics - pharmacology
Animals
Benzoxazines - pharmacology
Hindlimb - physiopathology
Hyperesthesia - etiology; physiopathology; psychology
Male
Morpholines - pharmacology
Naphthalenes - pharmacology
Nociceptors - drug effects
Pain Threshold

Physical Stimulation
Piperidines - pharmacology
Pyrazoles - pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1 - antagonists & inhibitors
Receptors, Cannabinoid - agonists
Spinal Cord Compression - complications
Spinal Cord Injuries - complications
Thoracic Vertebrae

Associated Chemicals: AM 251 (0) ; Analgesics (0) ; Benzoxazines (0) ; Morpholines (0) ; Naphthalenes (0) ; Piperidines (0) ; Pyrazoles (0) ; Receptor, Cannabinoid, CB1 (0) ; Receptors, Cannabinoid (0) ; Win 55212-2 (134959-51-6)

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