Research article summary (published 11 Oct 2006):

Efficacy and tolerability of OROS methylphenidate in Korean children with attention-deficit/hyperactivity disorder.

Full Abstract

This study evaluated the efficacy and tolerability in the initiation treatment of Concerta (OROS methylphenidate HCl) in Korean children with Attention-Deficit/Hyperactivity Disorder (AD/HD). One hundred and nineteen children with AD/HD were entered into a multi-center, open-label, four-week trial. The dosage of Concerta was adjusted by the investigators based on symptoms and safety assessments performed on a weekly basis. The safety of the drug and its efficacy for attention, behavior, and cognitive function were assessed. The primary outcome measures for efficacy were the Parent and Teacher IOWA Conners Rating Scales, Peer Interaction Items, and the Clinical Global Impression Scale. Cognitive tests (Continuous Performance Test, Matched Familiar Figure Test, Verbal Fluency Test, and Trail Making Test) were included as the secondary outcome measures. In most participants, OROS methylphenidate was well tolerated. There were significant improvements in attention, behavior, and function as measured by parents, teachers, and investigators. The benefit of the initiation of OROS methylphenidate in children with AD/HD was shown on the cognitive tests as well. These data provide support for the benefit of the once-daily methylphenidate preparation, Concerta in the treatment of Korean children with AD/HD. Children were initiated safely in this short-term trial, and its effectiveness was evident in the behavioral, as well as neuropsychological measurements.

Author information

Author/s: Lee, Soyoung Irene (SI); Hong, Sungdo David (SD); Kim, Sang-Yeup (SY); Kim, Eui-Jung (EJ); Kim, Ji-Hae (JH); Kim, Ji-Hoon (JH); Park, Mi-Kyoung (MK); Park, Sehyeon (S); Park, Joon-Ho (JH); Oh, Eun-Young (EY); Lim, Tae-Sik (TS); Cheong, Seongshim (S); Cho, In Hee (IH); Choi, Jee Wook (JW);

Affiliation: Department of Psychiatry, Soonchunhyang University Bucheon Hospital, College of Medicine, Soonchunhyang University, South Korea.

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry), published in England. (Language: eng)

Reference: 2007-Jan; vol 31 (issue 1) : pp 210-6

Dates: Created 2006/12/25; Completed 2007/03/15; Revised 2007/08/28;

PMID: 17046131, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1149-50; author reply 1151-2. (PMID: 17493730)

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adolescent Arousal - drug effects Attention - drug effects Attention Deficit Disorder with Hyperactivity - drug therapy; psychology Central Nervous System Stimulants - administration & dosage; adverse effects; therapeutic use Child Dose-Response Relationship, Drug Female Humans

Humans Impulsive Behavior - drug therapy Interpersonal Relations Korea Male Methylphenidate - administration & dosage; adverse effects; therapeutic use Neuropsychological Tests Psychomotor Performance - drug effects Verbal Behavior - drug effects

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Central Nervous System Stimulants (0) ; Methylphenidate (113-45-1)

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