Common Kibra alleles are associated with human memory performance.

Full Abstract

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

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Author information

Author/s: Papassotiropoulos, Andreas (A); Stephan, Dietrich A (DA); Huentelman, Matthew J (MJ); Hoerndli, Frederic J (FJ); Craig, David W (DW); Pearson, John V (JV); Huynh, Kim-Dung (KD); Brunner, Fabienne (F); Corneveaux, Jason (J); Osborne, David (D); Wollmer, M Axel (MA); Aerni, Amanda (A); Coluccia, Daniel (D); Hänggi, Jürgen (J); Mondadori, Christian R A (CR); Buchmann, Andreas (A); Reiman, Eric M (EM); Caselli, Richard J (RJ); Henke, Katharina (K); de Quervain, Dominique J-F (DJ);

Affiliation: Division of Psychiatry Research, University of Zurich, Zurich 8057, Switzerland. papas(-atsign-)bli.unizh.ch

Grants: P30AG19610 (Agency:NIA NIH HHS) ; R01MH057899 (Agency:NIMH NIH HHS) ; U01-HL086528-01 (Agency:NHLBI NIH HHS) ; U24NS051872 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Science (New York, N.Y.) (Science), published in United States. (Language: eng)

Reference: 2006-Oct; vol 314 (issue 5798) : pp 475-8

Dates: Created 2006/10/20; Completed 2006/10/30; Revised 2007/11/14;

PMID: 17053149, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Alleles
Animals
Attention
Brain - physiology
Brain Chemistry
Calcium-Binding Proteins - genetics
Cohort Studies
Female
Gene Expression
Genotype
Haplotypes

Hippocampus - chemistry; physiology
Humans
Magnetic Resonance Imaging
Male
Membrane Proteins - genetics
Memory
Mice
Middle Aged
Polymorphism, Single Nucleotide
Proteins - analysis; genetics; physiology
Reverse Transcriptase Polymerase Chain Reaction
Switzerland
United States

Associated Chemicals: CLSTN2 protein, human (0) ; Calcium-Binding Proteins (0) ; Membrane Proteins (0) ; Proteins (0) ; WWC1 protein, human (0)

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