Decrease in circulating glucose, insulin and leptin levels and improvement in insulin resistance at 1 and 3 months after gastric bypass.

Full Abstract

BACKGROUND:
Hyperglycemia, insulin resistance and hyperleptinemia are some of the consequences of obesity. Gastric bypass for morbid obesity provides gastric restriction with decreased energy absorption. To confirm and extend previous reports in the literature, we evaluated the plasma glucose, serum insulin and leptin and insulin resistance of patients preoperatively and 1 and 3 months after Roux-en-Y gastric bypass (RYGBP).METHODS:
We determined body mass index (BMI), plasma glucose (glucose-oxidase method), serum leptin (immunoassay) and insulin (chemiluminescent immunometric assay), and insulin resistance index (IRI) by Homeostasis Model Assessment (HOMA) of 20 patients with morbid obesity both preoperatively and 1 and 3 months after RYGBP.RESULTS:
Patients showed a mean decrease in weight of 8 kg/month. Glycemia was above reference levels in 65% of the preoperative patients but dropped significantly 1 month postoperatively, serum insulin and leptin levels and the HOMA index also decreasing significantly in the same period. The percentage of patients with preoperative elevated serum insulin and leptin relative to reference levels decreased significantly following RYGBP. We also observed a weak but significant correlation between BMI and glucose, BMI and insulin, and leptin and insulin.CONCLUSIONS:
The beneficial effects of bariatric surgery are already noticeable 1 month postoperatively, the reduction in insulin levels being more important for leptin reduction than decreased BMI. Leptin appeared to be subject to multifactorial control and showed a larger reduction than body weight.

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Author information

Author/s: Ramos, Adriana Pelegrino Pinho (AP); de Abreu, Márcia Regina Azevedo (MR); Vendramini, Regina Célia (RC); Brunetti, Iguatemy Lourenço (IL); Pepato, Maria Teresa (MT);

Affiliation: Laboratório de Análises Clínicas do Curso de Ciências Farmacêuticas da Universidade de Ribeirão Preto (UNAERP), Ribeirão Preto-SP, Brazil.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Obesity surgery (Obes Surg), published in England. (Language: eng)

Reference: 2006-Oct; vol 16 (issue 10) : pp 1359-64

Dates: Created 2006/10/24; Completed 2007/01/10; Revised 2007/12/05;

PMID: 17059747, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Blood Glucose - analysis
Chemiluminescent Measurements
Female
Gastric Bypass
Humans
Insulin - blood

Insulin Resistance
Leptin - blood
Male
Middle Aged
Obesity, Morbid - blood; physiopathology; surgery
Postoperative Period
Time Factors

Associated Chemicals: Blood Glucose (0) ; Leptin (0) ; Insulin (11061-68-0)

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