fMRI study of problem-solving after severe traumatic brain injury.

Full Abstract

OBJECTIVE:
To assess the cerebral correlates of the dysexecutive syndrome after diffuse severe traumatic brain injury (TBI).

METHODS:
Ten patients with sub-acute/chronic severe TBI without detectable focal cortical contusion and 11 matched healthy subjects were included in a parametric fMRI study using a planning task, the Tower of London.

RESULTS:
Brain activation in the left Dorsolateral Pre-frontal Cortex (DLPFC) and the Anterior Cingulate Cortex (ACC) was closely related to performance. Patients with TBI who performed the task efficiently showed, like healthy controls who obtained a similar pattern of performance, a large activation in the left DLPFC and a small activation in the ACC. In contrast, poor performance was associated with a reduced activation in these both regions.

CONCLUSION:
Problem-solving deficits after severe diffuse TBI could be related to an impaired activation of the DLPFC and of the ACC.

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Author information

Author/s: Cazalis, Fabienne (F); Feydy, Antoine (A); Valabrègue, Romain (R); Pélégrini-Issac, Mélanie (M); Pierot, Laurent (L); Azouvi, Philippe (P);

Affiliation: INSERM U 483, Paris, France. fabfab(-atsign-)ucla.edu

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Brain injury : [BI] (Brain Inj), published in England. (Language: eng)

Reference: 2006-Sep; vol 20 (issue 10) : pp 1019-28

Dates: Created 2006/10/24; Completed 2007/07/24;

PMID: 17060134, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Brain Injuries - physiopathology; psychology
Brain Mapping - methods
Case-Control Studies
Cognition Disorders - etiology; physiopathology
Female
Gyrus Cinguli - physiopathology

Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Male
Neuropsychological Tests
Prefrontal Cortex - physiopathology
Problem Solving
Reaction Time

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