Research article summary (published 30 Jul 2006):

[Experimental studies on antitussive, expectorant and antiasthmatic effects of extract from Citrus grandis var. tomentosa]

Full Abstract

OBJECTIVE: To observe the antitussive, expectorant and antiashmatic effects of the extract from Citrus grandist var. tomentosa. METHOD: The cough models induced by ammonia liquor in mice and citric acid in guines pigs were used to observe the antitussive effects. The methods of phenel red execretion in mice and phlegm displacement of rats were used to investigate the expectorant effects. Bronchial asthma model induced by histamine-acetylcholine in guinea pigs was used to observe the antiasthmatic effects. RESULT: The extract from the title plant could inhibit the cough induced by ammonia in mice, decrease the frequency of cough induced by citric acid in guineas pig and prolong the latent period of cough. The extract also could obviously increase phenol red output of trachea in mice, promote expectoration in rats and prolong the latent period of asthma induced by histamine-acetylcholine in guinea pigs. CONCLUSION: The extract from C. grandis var. tomenfosa has significant antitussive, expectorant and antiasthmatic effects.

Author information

Author/s: Li, Pei-Bo (PB); Ma, Yan (Y); Wang, Yong-Gang (YG); Su, Wei-Wei (WW);

Affiliation: College of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.

Journal and publication information

Publication Type: English Abstract; Journal Article; Research Support, Non-U.S. Gov't

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi), published in China. (Language: chi)

Reference: 2006-Aug; vol 31 (issue 16) : pp 1350-2

Dates: Created 2006/10/25; Completed 2007/11/20; Revised 2008/02/06;

PMID: 17061559, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acetylcholine Ammonia Animals Anti-Asthmatic Agents - administration & dosage; isolation & purification; therapeutic use Antitussive Agents - administration & dosage; isolation & purification; therapeutic use Asthma - chemically induced; drug therapy Citric Acid Citrus - chemistry Cough - chemically induced; drug therapy Dose-Response Relationship, Drug Drugs, Chinese Herbal - administration & dosage; isolation & purification; therapeutic use

Expectorants - administration & dosage; isolation & purification; therapeutic use Female Fruit - chemistry Guinea Pigs Histamine Male Mice Phytotherapy Plants, Medicinal - chemistry Rats Rats, Sprague-Dawley

Associated Chemicals: Anti-Asthmatic Agents (0) ; Antitussive Agents (0) ; Drugs, Chinese Herbal (0) ; Expectorants (0) ; Histamine (51-45-6) ; Acetylcholine (51-84-3) ; Ammonia (7664-41-7) ; Citric Acid (77-92-9)

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