[P21 expression in renal interstitial fibrosis and regulative effect of enalapril]

Full Abstract

OBJECTIVE: To investigate the expression of P21 in renal interstitial fibrosis rats and the effect of enalapril on it. METHODS: Sprague Dawley rats were randomly divided into 3 groups: a sham operation group,a unilateral urethral obstruction group, and an enalapril treatment group. The expression of P21 in renal tubular epithelial cells on the process was detected by immunohistochemistry at different time spots (7, 14, 21 d after UUO, sham-surgery or enalapril treatment). The expression of p21 mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Seven days after the surgery, significant differences were found in P21 expression between UUO and SOR renal tubular cells. With degree of interstitial fibrosis aggravating, P21 expression increased. Enalapril can inhibit its expression. CONCLUSION: In the kidney of UUO rats, P21 expression increased and enalapril possessed significant inhibitory effects on the procedure. P21 may participate in the pathogenesis of renal tubule-interstitial fibrosis.

Author information

Author/s: Xiao, Yun (Y); Tao, Li-jian (LJ); Damu, Tang (T); Jin, Ou (O); Zhou, Jian-hua (JH); Shen, Ming (M); Hu, Jing (J); Liu, Chun-yan (CY); Sun, Jian (J); Ning, Wang-bin (WB);

Affiliation: Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.

Journal and publication information

Publication Type: English Abstract; Journal Article

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban), published in China. (Language: chi)

Reference: 2006-Oct; vol 31 (issue 5) : pp 663-6, 670

Dates: Created 2006/10/25; Completed 2007/03/29;

PMID: 17062926, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Angiotensin-Converting Enzyme Inhibitors - pharmacology; therapeutic use
Animals
Enalapril - pharmacology; therapeutic use
Kidney Tubules - metabolism
Male
Nephrosclerosis - drug therapy; metabolism

Associated Chemicals: Angiotensin-Converting Enzyme Inhibitors (0) ; RNA, Messenger (0) ; Enalapril (75847-73-3) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)

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