M1 muscarinic acetylcholine receptor agonism alters sleep without affecting memory consolidation.

Full Abstract

Preclinical studies have implicated cholinergic neurotransmission, specifically M1 muscarinic acetylcholine receptor (mAChR) activation, in sleep-associated memory consolidation. In the present study, we investigated the effects of administering the direct M1 mAChR agonist RS-86 on pre-post sleep memory consolidation. Twenty healthy human participants were tested in a declarative word-list task and a procedural mirror-tracing task. RS-86 significantly reduced rapid eye movement (REM) sleep latency and slow wave sleep (SWS) duration in comparison with placebo. Presleep acquisition and postsleep recall rates were within the expected ranges. However, recall rates in both tasks were almost identical for the RS-86 and placebo conditions. These results indicate that selective M1 mAChR activation in healthy humans has no clinically relevant effect on pre-post sleep consolidation of declarative or procedural memories at a dose that reduces REM sleep latency and SWS duration.

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Author information

Author/s: Nissen, Christoph (C); Power, Ann E (AE); Nofzinger, Eric A (EA); Feige, Bernd (B); Voderholzer, Ulrich (U); Kloepfer, Corinna (C); Waldheim, Bernhard (B); Radosa, Marc-Philipp (MP); Berger, Mathias (M); Riemann, Dieter (D);

Affiliation: Albert-Ludwigs-University Freiburg, Germany. nissenc(-atsign-)upmc.edu

Journal and publication information

Publication Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial

Journal: Journal of cognitive neuroscience (J Cogn Neurosci), published in United States. (Language: eng)

Reference: 2006-Nov; vol 18 (issue 11) : pp 1799-807

Dates: Created 2006/10/30; Completed 2006/12/12;

PMID: 17069471, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Double-Blind Method
Drug Evaluation, Preclinical - methods
Female
Humans
Male
Mental Recall - drug effects

Mental Recall - drug effects
Multivariate Analysis
Muscarinic Agonists - pharmacology
Neuropsychological Tests
Reaction Time - drug effects
Sleep - drug effects
Succinimides - pharmacology

Associated Chemicals: Muscarinic Agonists (0) ; Succinimides (0) ; 2-ethyl-8-methyl-2,8-diazaspiro(4,5)decane-1,3-dione (3576-73-6)

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