Protective effects of Ginkgo biloba extract against mercury(II)-induced cardiovascular oxidative damage in rats.

Full Abstract

This study was designed to determine the possible protective effect of Ginkgo biloba extract (EGb) against Hg II-induced oxidative damage and also thromboplastic activity in the aorta and heart tissues. Wistar albino rats of either sex (200-250 g) were divided into four groups. Rats were injected intraperitoneally with (1) control (C) group:
0.9% NaCl; (2) EGb group:
Ginkgo biloba extract (Abdi Ibrahim Pharmaceutical Company, Istanbul, Turkey) at a dose of 50 mg/kg/day; (3) Hg group:
a single dose of 5 mg/kg mercuric chloride (HgCl(2)); and (4) Hg + EGb group:
First day EGb at a dose of 50 mg/kg/day, i.p., 1 hour after HgCl(2) (5 mg/kg) injection; following four days EGb at a dose 50 mg/kg/day, i.p. After decapitation of the rats, trunk blood was obtained and serum tumor necrosis factor-alpha (TNF-alpha), lactate dehydrogenase (LDH) activity, and malondialdehyde (MDA) and glutathione (GSH) levels were analysed. In the aorta and heart tissues total protein, MDA, GSH levels and thromboplastic activity were determined. The results revealed that HgCl(2) induced oxidative tissue damage, as evidenced by increases in MDA levels and decreased GSH levels both in serum and tissue samples. Thromboplastic activity was increased significantly following Hg administration, which verifies the cardiotoxic effects of HgCl(2). Serum LDH and TNF-alpha were elevated in the Hg group compared with the control group. Since EGb treatment reversed these responses, it seems likely that Ginkgo biloba extract can protect the cardiovascular tissues against HgCl(2)-induced oxidative damage.

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Author information

Author/s: Tunali-Akbay, Tugba (T); Sener, Goksel (G); Salvarli, Hanife (H); Sehirli, Ozer (O); Yarat, Aysen (A);

Affiliation: School of Dentistry, Department of Biochemistry, Marmara University, Turkey. ttunali(-atsign-)marmara.edu.tr

Journal and publication information

Publication Type: Journal Article

Journal: Phytotherapy research : PTR (Phytother Res), published in England. (Language: eng)

Reference: 2007-Jan; vol 21 (issue 1) : pp 26-31

Dates: Created 2006/12/26; Completed 2007/02/20;

PMID: 17072828, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Aorta, Thoracic - drug effects; metabolism
Cardiotonic Agents - administration & dosage; pharmacology; therapeutic use
Cardiovascular Diseases - chemically induced; prevention & control
Female
Ginkgo biloba
Glutathione - blood; metabolism
Heart - drug effects
Injections, Intraperitoneal
L-Lactate Dehydrogenase - blood; metabolism

L-Lactate Dehydrogenase - blood; metabolism
Lipid Peroxidation - drug effects
Male
Malondialdehyde - blood; metabolism
Mercuric Chloride - diagnostic use
Phytotherapy
Plant Extracts - administration & dosage; pharmacology; therapeutic use
Rats
Rats, Wistar
Tumor Necrosis Factor-alpha - blood

Associated Chemicals: Cardiotonic Agents (0) ; Plant Extracts (0) ; Tumor Necrosis Factor-alpha (0) ; Malondialdehyde (542-78-9) ; Glutathione (70-18-8) ; Mercuric Chloride (7487-94-7) ; L-Lactate Dehydrogenase (EC 1.1.1.27)

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