Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localization.

Full Abstract

BACKGROUND:
In this study we used event-related potentials (ERPs) and source localization analyses to track the time course of neural activity underlying response monitoring in children diagnosed with an anxiety disorder compared to age-matched low-risk normal controls.

METHODS:
High-density ERPs were examined following errors on a flanker task from 12 children between 8 and 14 years old diagnosed with an anxiety disorder (ANX) and 13 age-matched low-risk normal controls (LRNC).

RESULTS:
Children diagnosed with an anxiety disorder had increased error-related negativity (ERN) amplitude. The neural generators of the ERN in the ANX group were estimated to be localized in the anterior cingulate cortex (ACC). There were no significant group differences in P(E) amplitude.

CONCLUSIONS:
These data provide evidence for increased ERN amplitude localized to the ACC in children diagnosed with an anxiety disorder, suggesting altered maturational patterns of the ACC circuitry early in the course of this illness.

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Author information

Author/s: Ladouceur, Cecile D (CD); Dahl, Ronald E (RE); Birmaher, Boris (B); Axelson, David A (DA); Ryan, Neal D (ND);

Affiliation: Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA. ladouceurcd(-atsign-)upmc.edu

Grants: MH 67346 (Agency:NIMH NIH HHS) ; P01 MH 041712 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Journal of child psychology and psychiatry, and allied disciplines (J Child Psychol Psychiatry), published in England. (Language: eng)

Reference: 2006-Oct; vol 47 (issue 10) : pp 1073-82

Dates: Created 2006/10/31; Completed 2007/02/06; Revised 2007/12/03;

PMID: 17073986, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Anxiety Disorders - diagnosis; physiopathology; psychology
Child
Depressive Disorder - diagnosis; physiopathology; psychology
Electroencephalography
Evoked Potentials - physiology
Female

Frontal Lobe - physiopathology
Gyrus Cinguli - physiopathology
Humans
Male
Questionnaires
Reaction Time
Severity of Illness Index

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