DTNBP1 genotype influences cognitive decline in schizophrenia.

Full Abstract

OBJECTIVE:
Intellectual decline is common in schizophrenia and predicts functional outcome. While many patients undergo intellectual decline that typically predates the onset of symptoms, few studies have investigated the underlying mechanism through which this occurs. The current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1).

METHODS:
We assessed cognitive decline in 183 Caucasian patients with schizophrenia using a proxy measure of premorbid IQ with which current general cognitive ability (g) was compared. We then tested for a relationship between the risk haplotype identified in previous work (CTCTAC) and intellectual decline.

RESULTS:
We found that carriers of the CTCTAC haplotype, demonstrated a significantly greater decline in IQ as compared with non-carriers (p=0.05).

CONCLUSIONS:
These data suggest that DTNBP1 influences the severity of intellectual decline in schizophrenia and may represent one underlying cause for heterogeneity in cognitive course.

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Author information

Author/s: Burdick, Katherine E (KE); Goldberg, Terry E (TE); Funke, Birgit (B); Bates, John A (JA); Lencz, Todd (T); Kucherlapati, Raju (R); Malhotra, Anil K (AK);

Affiliation: Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, NY 11004, United States. kburdick(-atsign-)lij.edu

Grants: P30 MH060575-01 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Schizophrenia research (Schizophr Res), published in Netherlands. (Language: eng)

Reference: 2007-Jan; vol 89 (issue 1-3) : pp 169-72

Dates: Created 2006/12/18; Completed 2007/04/03; Revised 2008/11/20;

PMID: 17074466, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Carrier Proteins - genetics
Cognition Disorders - diagnosis; genetics; psychology
Disease Progression
Female
Genetic Predisposition to Disease - genetics
Genotype
Haplotypes
Heterozygote Detection

Humans
Intelligence - genetics
Male
Middle Aged
Psychotic Disorders - diagnosis; genetics; psychology
Risk Factors
Schizophrenia - diagnosis; genetics
Schizophrenic Psychology
Wechsler Scales

Associated Chemicals: Carrier Proteins (0) ; DTNBP1 protein, human (0)

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