Predictive value of amplitude-integrated electroencephalography pattern and voltage in asphyxiated term infants.

Full Abstract

The aim of this study was to correlate amplitude-integrated electroencephalography soon after birth with neurodevelopmental outcome in children who suffered from hypoxic-ischemic encephalopathy. Near term infants with hypoxic-ischemic encephalopathy and amplitude-integrated electroencephalography recording before 6 hours of age were included. Neurologic and cognitive outcome were assessed at 30 months of age and over. Outcome was correlated with either the pattern or voltage of the tracing. Thirty-nine infants were included. Eight died in the immediate neonatal period. At the age of 3 and 6 hours, sensitivity of low voltage to poor outcome was 33% and 42% respectively and of burst suppression pattern to poor outcome was 83% and 75% respectively. Association of voltage to outcome was significant only at 6 hours of age (P = 0.025). Association of pattern to outcome was significant both at 3 and 6 hours of age (P = 0.003, 0.008). These data on amplitude-integrated electroencephalography predictive value early in life were similar to previous studies. Burst suppression pattern, as early as 3 hours of age, is associated with poor outcome. At the age of 6 hours, both low voltage and burst suppression are associated with poor outcome. Pattern seems more sensitive than voltage.

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Author information

Author/s: Shany, Eilon (E); Goldstein, Esther (E); Khvatskin, Sonia (S); Friger, Michael D (MD); Heiman, Nurit (N); Goldstein, Miri (M); Karplus, Michael (M); Galil, Aharon (A);

Affiliation: Department of Neonatology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. eshany(-atsign-)bgu.ac.il

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Pediatric neurology (Pediatr Neurol), published in United States. (Language: eng)

Reference: 2006-Nov; vol 35 (issue 5) : pp 335-42

Dates: Created 2006/10/31; Completed 2007/01/30;

PMID: 17074604, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Asphyxia Neonatorum - complications; physiopathology
Brain - physiopathology
Child Development - physiology
Child, Preschool
Cohort Studies
Electroencephalography
Female

Humans
Hypoxia-Ischemia, Brain - etiology; physiopathology; psychology
Infant
Infant, Newborn
Male
Neurologic Examination
Predictive Value of Tests

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