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| Research article summary (published 11 Nov 2006): |
Methoxy-substituted TQEN family of fluorescent zinc sensors.
Full Abstract
Two methoxy-substituted TQEN (N,N,N',N'-tetrakis(2-quinolylmethyl)ethylenediamine) derivatives, T(MQ)EN (N,N,N',N'-tetrakis(6-methoxy-2-quinolylmethyl)ethylenediamine) and T(TMQ)EN (N,N,N',N'-tetrakis(5,6,7-trimethoxy-2-quinolylmethyl)ethylenediamine), have been prepared, and their fluorescence properties with respect to Zn2+ coordination were investigated. Introduction of a methoxy substituent at 6-position of the quinoline ring enhances the fluorescence intensity by 10-fold, and the three methoxy substituents in the 5,6,7-positions afford significant enhancement of the long-wavelength component of the fluorescence of zinc complex. The substituents did not alter the binding affinity of these compounds toward zinc ion significantly. T(MQ)EN was proved to be effective in detection of zinc ion in cells by fluorescent microscopy.
Author information
Author/s: Mikata, Yuji (Y); Wakamatsu, Motoko (M); Kawamura, Ayano (A); Yamanaka, Natsuko (N); Yano, Shigenobu (S); Odani, Akira (A); Morihiro, Kazuko (K); Tamotsu, Satoshi (S);
Affiliation: KYOUSEI Science Center, Division of Material Science, and Department of Biological Sciences, Nara Women's University, Nara 630-8506, Japan. mikata(-atsign-)cc.nara-wu.ac.jp
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Inorganic chemistry (Inorg Chem), published in United States. (Language: eng)
Reference: 2006-Nov; vol 45 (issue 23) : pp 9262-8
Dates: Created 2006/11/06; Completed 2007/05/31;
PMID: 17083225, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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