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| Research article summary (published 29 Nov 2006): |
Genetic predictors of acute and chronic pain.
Full Abstract
Although broad agreement exists that genetic factors are important contributors to individual differences in pain sensitivity and risk for developing painful clinical conditions, the field of pain genetics is still in its infancy. This article reviews recent human studies of the genetics of acute and chronic pain, which implicate polymorphisms in genes coding for catechol-O-methyltransferase activity and micro-opioid receptors, among a number of others, as influential in explaining variability among the pain responses of individuals. Growing interest in pain genetics and accelerating methodologic advances in the field will almost certainly alter our understanding of which genes contribute to nociception and how dynamic interactions between multiple genes and environmental events shape the human experience of pain.
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Author information
Author/s: Edwards, Robert R (RR);
Affiliation: Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Meyer 1-108, Baltimore, MD 21287, USA. redwar10(-atsign-)jhmi.edu
Grants: K23-AR051315 (Agency:NIAMS NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review
Journal: Current rheumatology reports (Curr Rheumatol Rep), published in United States. (Language: eng)
Reference: 2006-Dec; vol 8 (issue 6) : pp 411-7
Dates: Created 2006/11/09; Completed 2007/02/01; Revised 2007/12/03;
PMID: 17092439, status: MEDLINE (last retrieval date: 12/26/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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