Lower urinary tract symptoms and bladder control in advanced Parkinson's disease: effects of deep brain stimulation in the subthalamic nucleus.

Full Abstract

Deep brain stimulation in the subthalamic nucleus (STN) leads to significant improvement in motor function in patients with advanced Parkinson's disease (PD). In this prospective study including 16 patients with PD, we investigated (1) lower urinary tract symptoms (LUTS) by questionnaires International Prostate Symptom Score (IPSS, symptoms only) and Danish Prostate Symptom Score (DanPSS, symptoms and bother of symptoms) and (2) bladder control (assessed by urodynamics) before and after implantation of electrodes in the STN. PD symptoms (Unified Parkinson's Disease Rating Scale score) improved significantly (P < 0.0001), and symptoms of overactive bladder (IPSS) decreased along with the troublesome symptoms of overactive bladder (DanPSS; P < 0.01 for both). Urodynamic parameters before and after implantation of electrodes in the STN, evaluated with and without the stimulation on, did not change significantly. (c) 2006 Movement Disorder Society.

Author information

Author/s: Winge, Kristian (K); Nielsen, Kurt Krøyer (KK); Stimpel, Hans (H); Lokkegaard, Annemette (A); Jensen, Steen Rusborg (SR); Werdelin, Lene (L);

Affiliation: Copenhagen Movement Disorders Centre, H:S Bispebjerg Hospital, Copenhagen NV, Denmark. k.winge(-atsign-)dadlnet.dk

Journal and publication information

Publication Type: Journal Article

Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord), published in United States. (Language: eng)

Reference: 2007-Jan; vol 22 (issue 2) : pp 220-5

Dates: Created 2007/02/05; Completed 2007/03/23;

PMID: 17133504, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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