Research article summary (published 29 Nov 2006):

Abietane diterpenoids from Salvia pachyphylla and S. clevelandii with cytotoxic activity against human cancer cell lines.

Full Abstract

A phytochemical study has been carried out on the aerial parts of Salvia pachyphylla and S. clevelandii. From S. pachyphylla, the known diterpenes carnosol (2), rosmanol, 20-deoxocarnosol (3), carnosic acid, isorosmanol (4), 7-methoxyrosmanol, 5,6-didehydro-O-methylsugiol (5), 8beta-hydroxy-9(11),13-abietadien-12-one (6), 11,12-dioxoabieta-8,13-diene, and 11,12-dihydroxy-20-norabieta-5(10),8,11,13-tetraen-1-one were isolated, together with the new diterpene pachyphyllone (1). From S. clevelandii, the known diterpenes rosmadial (7), 16-hydroxycarnosol (8), abieta-8,11,13-triene, and taxodone were obtained, together with carnosol (2), rosmanol, and carnosic acid. The structure of the new compound (1) was identified on the basis of spectroscopic data analysis. Several of these compounds (1-8) were evaluated against a small panel of human cancer cell lines.

Author information

Author/s: Guerrero, Ivan C (IC); Andrés, Lucía S (LS); León, Leticia G (LG); Machín, Rubén P (RP); Padrón, José M (JM); Luis, Javier G (JG); Delgadillo, José (J);

Affiliation: Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Calzada Tecnológico 14418, Mesa de Otay, C.P. 22390 Tijuana, Baja California, Mexico.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of natural products (J Nat Prod), published in United States. (Language: eng)

Reference: 2006-Dec; vol 69 (issue 12) : pp 1803-5

Dates: Created 2006/12/27; Completed 2007/01/31;

PMID: 17190465, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Antineoplastic Agents, Phytogenic - chemistry; isolation & purification; pharmacology Cell Line, Tumor Diterpenes, Abietane - chemistry; isolation & purification; pharmacology Drug Screening Assays, Antitumor

Humans Mexico Molecular Structure Plants, Medicinal - chemistry Salvia - chemistry

Associated Chemicals: Antineoplastic Agents, Phytogenic (0) ; Diterpenes, Abietane (0) ; pachyphyllone (0)

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