Evaluation of chiral ionic liquids as additives to cyclodextrins for enantiomeric separations by capillary electrophoresis.

Full Abstract

A great interest has been drawn these last years towards ionic liquids in analytical chemistry, especially for separation methods. Recent synthesis of chiral ILs opened the way of the evaluation of new potential selectors for enantiomeric separations. This work focused on the evaluation of two chiral ILs (ethyl- and phenylcholine of bis(trifluoromethylsulfonyl)imide) by CE. Particular selectivities are awaited by exploiting unique ion-ion or ion-dipole interactions and by tailoring the nature of the cation and the anion. To evaluate such phenomena, a study was carried out with anti-inflammatory drugs 2-arylpropionic acids as model compounds. The results show that these chiral ILs did not present direct enantioselectivity with regard to these model analytes. The influence of chiral ILs in the electrolytes was then studied in the presence of classical chiral selectors (di- or trimethyl-beta-cyclodextrin). Although no general trend could be established, an increase in separation selectivity and resolution was observed in some cases, suggesting synergistic effects. The complementary determination of apparent inclusion constant values of these IL cations in the used cyclodextrins by affinity CE provided support to the understanding of the phenomena involved.

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Author information

Author/s: François, Yannis (Y); Varenne, Anne (A); Juillerat, Emilie (E); Villemin, Didier (D); Gareil, Pierre (P);

Affiliation: Laboratory of Electrochemistry and Analytical Chemistry, UMR CNRS 7575, ENSCP, Paris Cedex 05, France.

Journal and publication information

Publication Type: Evaluation Studies; Journal Article

Journal: Journal of chromatography. A (J Chromatogr A), published in Netherlands. (Language: eng)

Reference: 2007-Jul; vol 1155 (issue 2) : pp 134-41

Dates: Created 2007/06/18; Completed 2007/08/10;

PMID: 17222416, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Cyclodextrins - isolation & purification
Electrophoresis, Capillary - methods

Ionic Liquids - chemical synthesis; chemistry
Stereoisomerism

Associated Chemicals: Cyclodextrins (0) ; Ionic Liquids (0)

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