Do serotonin(1-7) receptors modulate short and long-term memory?

Full Abstract

Evidence from invertebrates to human studies indicates that serotonin (5-hydroxytryptamine; 5-HT) system modulates short- (STM) and long-term memory (LTM). This work is primarily focused on analyzing the contribution of 5-HT, cholinergic and glutamatergic receptors as well as protein synthesis to STM and LTM of an autoshaping learning task. It was observed that the inhibition of hippocampal protein synthesis or new mRNA did not produce a significant effect on autoshaping STM performance but it did impair LTM. Both non-contingent protein inhibition and 5-HT depletion showed no effects. It was basically the non-selective 5-HT receptor antagonist cyproheptadine, which facilitated STM. However, the blockade of glutamatergic and cholinergic transmission impaired STM. In contrast, the selective 5-HT(1B) receptor antagonist SB-224289 facilitated both STM and LTM. Selective receptor antagonists for the 5-HT(1A) (WAY100635), 5-HT(1D) (GR127935), 5-HT(2A) (MDL100907), 5-HT(2C/2B) (SB-200646), 5-HT(3) (ondansetron) or 5-HT(4) (GR125487), 5-HT(6) (Ro 04-6790, SB-399885 and SB-35713) or 5-HT(7) (SB-269970) did not impact STM. Nevertheless, WAY100635, MDL100907, SB-200646, GR125487, Ro 04-6790, SB-399885 or SB-357134 facilitated LTM. Notably, some of these changes shown to be independent of food-intake. Concomitantly, these data indicate that '5-HT tone via 5-HT(1B) receptors' might function in a serial manner from STM to LTM, whereas working in parallel using 5-HT(1A), 5-HT(2A), 5-HT(2B/2C), 5-HT(4), or 5-HT(6) receptors.

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Author information

Author/s: Meneses, A (A);

Affiliation: Depto de Farmacobiología, CINVESTAV-IPN, Tenorios 235, Granjas Coapa, México City, Mexico. ameneses(-atsign-)msn.com

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neurobiology of learning and memory (Neurobiol Learn Mem), published in United States. (Language: eng)

Reference: 2007-May; vol 87 (issue 4) : pp 561-72

Dates: Created 2007/04/02; Completed 2007/07/16; Revised 2007/10/17;

PMID: 17224282, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance
Animals
Conditioning, Classical - drug effects; physiology
Exploratory Behavior - drug effects; physiology
Male
Memory - drug effects; physiology
Nerve Tissue Proteins - biosynthesis
Protein Biosynthesis - drug effects; physiology

Protein Biosynthesis - drug effects; physiology
Rats
Rats, Wistar
Receptors, Serotonin - classification; drug effects; physiology
Retention (Psychology) - drug effects; physiology
Serotonin Agents - pharmacology
Statistics, Nonparametric
Time Factors

Associated Chemicals: Nerve Tissue Proteins (0) ; Receptors, Serotonin (0) ; Serotonin Agents (0)

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