[Studies on HPLC fingerprint of cortex moutan]

Full Abstract

OBJECTIVE:
To establish a HPLC fingerprint for quality evaluation of Cortex Moutan.

METHOD:
The HPLC chromatographic fingerprinting of 30 lots of Cortex Moutan was established and major peaks were identified by LC-MS and MS-MS.

RESULT:
The HPLC fingerprint of Cortex Moutan was established, showing 15 characteristic peaks. The areas of these peaks were found to complied with the following rule:
paeonol > 1, 2, 3, 4, 6-penta-O-galloyl-glucos > methyl gallate > galloylpaeoniflorin > gallic acid > oxypaeoniflorin > other compounds.

CONCLUSION:
The chromatographic fingerprinting of Cortex Moutan with high specificity can be used to control its quality and monitor lot to lot consistency.

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Author information

Author/s: Xu, Shun-Jun (SJ); Li, Peng (P); Yang, Liu (L); Zhang, Mian (M); Wang, Zheng-Tao (ZT);

Affiliation: Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China.

Journal and publication information

Publication Type: English Abstract; Journal Article; Research Support, Non-U.S. Gov't

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi), published in China. (Language: chi)

Reference: 2006-Oct; vol 31 (issue 20) : pp 1677-80

Dates: Created 2007/01/17; Completed 2007/11/26; Revised 2008/02/06;

PMID: 17225532, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acetophenones - analysis
Bicyclo Compounds, Heterocyclic - analysis
Chromatography, High Pressure Liquid - methods
Drugs, Chinese Herbal - analysis; chemistry; classification
Gallic Acid - analogs & derivatives; analysis
Glucosides - analysis

Hydrolyzable Tannins - analysis
Monoterpenes - analysis
Paeonia - chemistry; classification
Plant Bark - chemistry
Plants, Medicinal - chemistry
Quality Control

Associated Chemicals: Acetophenones (0) ; Bicyclo Compounds, Heterocyclic (0) ; Drugs, Chinese Herbal (0) ; Glucosides (0) ; Hydrolyzable Tannins (0) ; Monoterpenes (0) ; galloylpaeoniflorin (0) ; moutan cortex (0) ; Gallic Acid (149-91-7) ; beta-penta-O-galloyl-glucose (14937-32-7) ; oxypaeoniflora (39011-91-1) ; paeonol (552-41-0) ; methyl gallate (99-24-1)

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