Patient-reported outcomes with botulinum toxin type A treatment of glabellar rhytids: a double-blind, randomized, placebo-controlled study.

Full Abstract

BACKGROUND:
Global patient-reported outcomes do not evaluate specific aspects of treatment that are important to patients.

OBJECTIVE:
The objective was to evaluate self-perception of age and specific outcomes that are important to patients receiving botulinum toxin type A or placebo for moderate to severe glabellar lines (using the Facial Line Outcomes Questionnaire to assess how much facial lines bother them, make them look older, detract from their facial appearance, prevent a smooth facial appearance, and make them look tired, stressed, or angry).

METHODS AND MATERIALS:
In the double-blind phase of this 12-week study, 70 patients were randomly assigned to treatment with 20 U botulinum toxin type A (BOTOX Cosmetic) or placebo. At Week 4, those still with moderate or severe glabellar lines were offered open-label 20 U botulinum toxin type A.

RESULTS:
Median glabellar line severity was significantly lower after botulinum toxin treatment than after placebo. Compared with placebo, botulinum toxin also resulted in significantly superior patient assessments and a greater proportion of patients considering they looked younger than their current age.

CONCLUSIONS:
Botulinum toxin type A can achieve specific goals of treatment that are important to patients and help them feel that they look younger than their current age.

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Author information

Author/s: Fagien, Steven (S); Cox, Sue Ellen (SE); Finn, J Charles (JC); Werschler, W Philip (WP); Kowalski, Jonathan W (JW);

Affiliation: Private Practice Aesthetic Oculoplastic Surgery, Boca Raton, Florida 33431, USA. sfagien(-atsign-)aol.com

Journal and publication information

Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg), published in United States. (Language: eng)

Reference: 2007-Jan; vol 33 (issue 1 Spec No.) : pp S2-9

Dates: Created 2007/01/23; Completed 2007/02/23;

PMID: 17241410, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Botulinum Toxin Type A - administration & dosage
Double-Blind Method
Female
Humans
Middle Aged

Neuromuscular Agents - administration & dosage
Patient Satisfaction
Questionnaires
Self Concept
Skin Aging - drug effects
Treatment Outcome

Associated Chemicals: Botulinum Toxin Type A (0) ; Neuromuscular Agents (0)

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