Can patients with epilepsy predict their seizures?

Full Abstract

OBJECTIVE:
To examine seizure predictability in a cohort of adult patients using a prospective seizure diary study, to assess the validity of a patient's predictions, and to determine if a subgroup of patients with epilepsy were able to reliably predict their seizures.

METHODS:
Eligible subjects were 18 or older, had localization-related epilepsy, had > or =1 seizure within 12 months, and were able to self-maintain a seizure diary. Seizure self-prediction was assessed by a rating scale:
"Do you think you will have a seizure in the next 24 hours?" Seizure prediction and seizure occurrence were modeled as binary outcomes. OR, positive predictive value, and negative predictive value were calculated for group and individuals, adjusted for the within person correlations.

RESULTS:
Seventy-one subjects returned 15,635 diary entries. A positive prediction of seizures was associated with a twofold increased risk of seizure (Cochran-Mantel-Haenszel OR 2.25 (1.91 to 2.65). Overall, the specificity of positive prediction was 83.2% while the sensitivity was 31.9%. Twelve subjects (21% of subjects who had seizures) demonstrated significant within person OR; Cochran-Mantel-Haenszel OR for positive prediction in this predictor subgroup 3.14 (2.53 to 3.89). Predictors were younger (p = 0.026) and had a higher seizure rate (p = 0.003) than nonpredictors.

CONCLUSIONS:
A significant subgroup of our adult patients with epilepsy were able to self-predict their seizures, which may yield novel therapeutic opportunities.

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Author information

Author/s: Haut, Sheryl R (SR); Hall, Charles B (CB); LeValley, Aaron J (AJ); Lipton, Richard B (RB);

Affiliation: Comprehensive Epilepsy Management Center, Montefiore Medical Centerand the Albert Einstein College of Medicine, Bronx, NY 10467-2490, USA. haut(-atsign-)aecom.yu.edu

Grants: K23 NS02192 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

Journal: Neurology (Neurology), published in United States. (Language: eng)

Reference: 2007-Jan; vol 68 (issue 4) : pp 262-6

Dates: Created 2007/01/23; Completed 2007/02/21; Revised 2007/11/14;

PMID: 17242331, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Neurology. 2007 Jan 23;68(4):250-1. (PMID: 17242329)

CommentIn: Neurology. 2007 Jul 31;69(5):494; author reply 494. (PMID: 17664414)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Age Factors
Cohort Studies
Epilepsy - epidemiology; physiopathology
Female
Humans

Humans
Male
Medical Records
Predictive Value of Tests
Prospective Studies
Seizures - epidemiology; physiopathology

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