Bioinformatics approaches in glycomics and drug discovery.

Full Abstract

Within the field of bioinformatics, interest in glycan structures has increased steadily since the start of the 21st century, with several databases worldwide accumulating data. The most notable publicly available databases are KEGG GLYCAN in Japan, glycoSCIENCES.de in Germany and that of the Consortium for Functional Glycomics in the US. With this increasing abundance of data, there are greater possibilities for applying tree-based models and algorithms to glycan structure data. Research in this area of glycome informatics is reviewed. The combination of these datasets and informatics techniques to enable extraction of the most important (and perhaps the most interesting) information--the links between glycans and diseases, and the identification of biomarkers and drug targets--is discussed.

Learn Faster Today Improve your study skills

Author information

Author/s: Aoki-Kinoshita, Kiyoko F (KF); Kanehisa, Minoru (M);

Affiliation: Soka University, Faculty of Engineering, Department of Bioinformatics, 1-236 Tangi-cho, Hachioji-shi, Tokyo 192-8577, Japan. kkiyoko(-atsign-)t.soka.ac.jp

Journal and publication information

Publication Type: Journal Article; Review

Journal: Current opinion in molecular therapeutics (Curr Opin Mol Ther), published in England. (Language: eng)

Reference: 2006-Dec; vol 8 (issue 6) : pp 514-20

Dates: Created 2007/01/24; Completed 2007/02/20;

PMID: 17243487, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Glycosylation
Humans
Polysaccharides - chemistry; genetics

Associated Chemicals: Polysaccharides (0)

These are the highest related articles currently in the database:

See 100+ related articles.