Delayed access to alcohol accelerates self-administration of alcohol on a progressive ratio schedule.

Full Abstract

In a previous report, we found that a 5-min. delay in alcohol access increases ethanol intake in rats trained to self-administer 5% ethanol. To assess the effects of this delay on the motivation to self-administer ethanol, Wistar rats were trained on a progressive ratio schedule of reinforcement and presented with the 5-min. delay. There was no change in break point (6 presses/delivery), active (125 presses/30 min.) or inactive (10 presses/30 min.) lever presses after the 5-min. delay compared to baseline. However, response cessation occurred 10 min. earlier in this delay session compared to baseline indicating that consumption was accelerated by delayed access to alcohol.

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Author information

Author/s: Pickering, Chris (C); Moreira, Tiago (T); Liljequist, Sture (S);

Affiliation: Department of Clinical Neuroscience, Division of Drug Dependence Research, Karolinska Institutet, Stockholm, Sweden. chris.pickering(-atsign-)ki.se

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Basic & clinical pharmacology & toxicology (Basic Clin Pharmacol Toxicol), published in Denmark. (Language: eng)

Reference: 2007-Feb; vol 100 (issue 2) : pp 109-14

Dates: Created 2007/01/24; Completed 2007/03/28;

PMID: 17244259, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alcohol Drinking - psychology
Animals
Central Nervous System Depressants - administration & dosage
Ethanol - administration & dosage
Male
Motivation

Associated Chemicals: Central Nervous System Depressants (0) ; Ethanol (64-17-5)

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