Biology and therapy of fibromyalgia. Functional magnetic resonance imaging findings in fibromyalgia.

Full Abstract

Techniques in neuroimaging such as functional magnetic resonance imaging (fMRI) have helped to provide insights into the role of supraspinal mechanisms in pain perception. This review focuses on studies that have applied fMRI in an attempt to gain a better understanding of the mechanisms involved in the processing of pain associated with fibromyalgia. This article provides an overview of the nociceptive system as it functions normally, reviews functional brain imaging methods, and integrates the existing literature utilizing fMRI to study central pain mechanisms in fibromyalgia.

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Author information

Author/s: Williams, David A (DA); Gracely, Richard H (RH);

Affiliation: Chronic Pain and Fatigue Research Center, Department of Internal Medicine, Division of Rheumatology, University of Michigan Health System, University of Michigan, Ann Arbor, MI, USA. daveawms(-atsign-)umich.edu

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review

Journal: Arthritis research & therapy (Arthritis Res Ther), published in England. (Language: eng)

Reference: 2006-; vol 8 (issue 6) : pp 224

Dates: Created 2007/04/02; Completed 2007/04/20; Revised 2008/11/20;

PMID: 17254318, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analgesics - therapeutic use
Brain Mapping
Cognitive Therapy - methods
Female
Fibromyalgia - diagnosis; epidemiology; therapy
Humans
Magnetic Resonance Imaging - methods
Male
Nociceptors - physiopathology

Nociceptors - physiopathology
Pain Measurement
Pain Threshold
Prognosis
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Somatosensory Cortex - pathology; physiopathology
Tomography, Emission-Computed, Single-Photon - methods

Associated Chemicals: Analgesics (0)

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