Effects of pre-germinated brown rice on depression-like behavior in mice.

Full Abstract

We investigated the antidepressant-like effects of pre-germinated brown rice (PGBR) and polished rice (PR) pellets, respectively, in comparison with control (AIN-93G) pellets in the forced swimming test and the learned helplessness paradigm in mice. Mice were fed respective pellets for 30 days. The immobility time on the 2nd day of the forced swimming test was shorter in mice fed with PR or PGBR pellets than in mice fed with control pellets. In the learned helplessness paradigm, the number of escape failures in mice fed with PGBR pellets was significantly smaller than that in mice fed with control pellets. Compared to the control group, an increase in serotonin (5-HT) levels, but not in 5-hydroxyindoleacetic acid (5-HIAA) levels, and a decrease in the 5-HIAA/5-HT ratio were observed in the frontal cortex of the PGBR group. There were no differences among the three groups in terms of 5-HT and 5-HIAA levels and their ratios in the hippocampus and striatum. The levels of noradrenaline and 3-methoxy-4-hydroxyphenylglycol were not affected by the food pellets in all the brain regions tested. Additionally, we could not detect any differences in the expression of the 5-HT1A receptor and the 5-HT transporter in the frontal cortex of the three groups. These results suggest that the increase of 5-HT levels in the mouse frontal cortex contributes to the antidepressant-like effects of PGBR pellets.

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Author information

Author/s: Mamiya, Takayoshi (T); Kise, Mitsuo (M); Morikawa, Keiko (K); Aoto, Hiromichi (H); Ukai, Makoto (M); Noda, Yukihiro (Y);

Affiliation: Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan. mamiya(-atsign-)ccmfs.meijo-u.ac.jp

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in United States. (Language: eng)

Reference: 2007-Jan; vol 86 (issue 1) : pp 62-7

Dates: Created 2007/02/26; Completed 2007/05/22;

PMID: 17258802, status: MEDLINE (last retrieval date: 2/18/2009)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Behavior, Animal - drug effects
Blotting, Western
Brain Chemistry - physiology
Depression - psychology
Diet
Helplessness, Learned
Hippocampus - metabolism
Hydroxyindoleacetic Acid - metabolism
Male
Methoxyhydroxyphenylglycol - metabolism
Mice

Mice
Mice, Inbred ICR
Motor Activity - physiology
Neostriatum - metabolism
Norepinephrine - metabolism
Oryza sativa
Pain Measurement
Prefrontal Cortex - metabolism
Receptor, Serotonin, 5-HT1A - metabolism
Serotonin - metabolism
Serotonin Plasma Membrane Transport Proteins - metabolism
Swimming - psychology

Associated Chemicals: Serotonin Plasma Membrane Transport Proteins (0) ; Receptor, Serotonin, 5-HT1A (112692-38-3) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; Methoxyhydroxyphenylglycol (534-82-7) ; Hydroxyindoleacetic Acid (54-16-0)

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