Research article summary (published 25 Jan 2007):

Dried blood spot measurement of tacrolimus is promising for patient monitoring.

Full Abstract

The usefulness of dried blood spot (DBS) sampling for therapeutic drug monitoring of tacrolimus was investigated with renal transplant patients. There was no significant difference between the concentrations (ranging 3.33-53.9 mug/l) of 34 samples of 26 stable renal transplant outpatients, measured both after venous and DBS sampling. DBS sampling is easy to perform because concentrations with and without nurse assistance did not significantly differ. No significant difference was found between tacrolimus concentrations in 20 duplicate DBS samples before and after postal transport. DBS seems promising for routine patient monitoring.

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Author information

Author/s: Hoogtanders, Karin (K); van der Heijden, Jaques (J); Christiaans, Maarten (M); van de Plas, Afke (A); van Hooff, Johannes (J); Stolk, Leo (L);

Affiliation: Department of Clinical Pharmacy, University Hospital of Maastricht, Maastricht, the Netherlands.

Journal and publication information

Publication Type: Evaluation Studies; Journal Article

Journal: Transplantation (Transplantation), published in United States. (Language: eng)

Reference: 2007-Jan; vol 83 (issue 2) : pp 237-8

Dates: Created 2007/01/31; Completed 2007/03/06;

PMID: 17264824, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Desiccation Drug Monitoring - methods Graft Rejection - immunology; prevention & control Humans

Humans Immunosuppressive Agents - blood; pharmacology Kidney Transplantation - immunology Tacrolimus - blood; pharmacology

Associated Chemicals: Immunosuppressive Agents (0) ; Tacrolimus (109581-93-3)

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