A comparison of medication side effect reports by panic disorder patients with and without concomitant cognitive behavior therapy.

Full Abstract

OBJECTIVE:
The authors assessed whether adding cognitive behavior therapy (CBT) to imipramine for patients with panic disorder decreased the severity of side effects and dropouts from side effects.

METHOD:
Data were analyzed for 172 panic disorder patients who were randomly assigned to receive imipramine alone, imipramine plus CBT, or placebo. Mixed-effects models were used to assess longitudinal differences among the treatment groups with respect to side effect burden and dropout rates during the acute, maintenance, and follow-up phases of treatment.

RESULTS:
Patients treated with imipramine plus CBT experienced less severe fatigue/weakness, dry mouth, and sweating and had a lower rate of dropout due to side effects compared with those treated with imipramine only.

CONCLUSIONS:
The addition of CBT to medication treatment with imipramine was associated with less severe side effects and fewer dropouts due to perceived side effects than treatment with imipramine alone.

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Author information

Author/s: Marcus, Sue M (SM); Gorman, Jack (J); Shear, M Katherine (MK); Lewin, David (D); Martinez, Jose (J); Ray, Susan (S); Goetz, Raymond (R); Mosovich, Serge (S); Gorman, Lauren (L); Barlow, David (D); Woods, Scott (S);

Affiliation: Mount Sinai School of Medicine, Department of Psychiatry, Division of Biostatistics, Box 1230, One Gustave L. Levy Place, New York, NY 10029-6574. sue.marcus(-atsign-)mssm.edu.

Grants: MH00416 (Agency:NIMH NIH HHS) ; MH45963 (Agency:NIMH NIH HHS) ; MH45964 (Agency:NIMH NIH HHS) ; MH45965 (Agency:NIMH NIH HHS) ; MH45966 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural

Journal: The American journal of psychiatry (Am J Psychiatry), published in United States. (Language: eng)

Reference: 2007-Feb; vol 164 (issue 2) : pp 273-5

Dates: Created 2007/02/01; Completed 2007/04/05; Revised 2007/12/03;

PMID: 17267790, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Antidepressive Agents, Tricyclic - adverse effects; therapeutic use
Cognitive Therapy
Combined Modality Therapy
Fatigue - chemically induced
Humans
Hyperhidrosis - chemically induced
Imipramine - adverse effects; therapeutic use

Imipramine - adverse effects; therapeutic use
Panic Disorder - drug therapy; prevention & control; therapy
Patient Dropouts - statistics & numerical data
Placebos
Severity of Illness Index
Sweating - drug effects
Xerostomia - chemically induced

Associated Chemicals: Antidepressive Agents, Tricyclic (0) ; Placebos (0) ; Imipramine (50-49-7)

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