The place of targeted therapies in the management of non-small cell bronchial carcinoma. Molecular markers as predictors of tumor response and survival in lung cancer.

Full Abstract

This review highlights the numerous molecular biology findings in the field of lung cancer with potential therapeutic impact in both the near and distant future. Abundant pre-clinical and clinical data indicate that BRCA1 mRNA expression is a differential modulator of chemotherapy sensitivity. Low levels predict cisplatin sensitivity and antimicrotubule drug resistance, and the opposite occurs with high levels. The main core of recent research has centered on epidermal growth factor receptor (EGFR) mutations and gene copy numbers. For the first time, EGFR mutations have been shown to predict dramatic responses in metastatic lung adenocarcinomas, with a threefold increase in time to progression and survival in patients receiving EGFR tyrosine-kinase inhibitors. Evidence has also been accumulated on the crosstalk between estrogen and EGFR receptor pathways, paving the way for clinical trials of EGFR tyrosine-kinase inhibitors plus aromatase inhibitors. Understanding the relevance of these findings can help to change the clinical practice in oncology towards customizing chemotherapy and targeted therapies, leading to improvement both in survival and in cost-effectiveness.

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Author information

Author/s: Rosell, R (R); Moran, T (T); Fernanda Salazar, M (M); Mendez, P (P); De Aguirre, I (I); Ramirez, J-L (JL); Isla, D (D); Cobo, M (M); Camps, C (C); Lopez-Vivanco, G (G); Alberola, V (V); Taron, M (M);

Affiliation: Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain. rrosell(-atsign-)ico.scs.es

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Revue des maladies respiratoires (Rev Mal Respir), published in France. (Language: eng)

Reference: 2006-Nov; vol 23 (issue 5 Pt 3) : pp 16S131-16S136

Dates: Created 2007/02/01; Completed 2007/06/27;

PMID: 17268350, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Biological Markers
Carcinoma, Bronchogenic - drug therapy; genetics; mortality
Carcinoma, Non-Small-Cell Lung - drug therapy; genetics; mortality
Humans

Lung Neoplasms - drug therapy; genetics; mortality
Mutation
Prognosis
Survival Rate

Associated Chemicals: Biological Markers (0)

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