Near infrared spectroscopy in the development of solid dosage forms.

Full Abstract

The use of near infrared (NIR) spectroscopy has rapidly grown partly due to demands of process analytical applications in the pharmaceutical industry. Furthermore, newest regulatory guidelines have advanced the increase of the use of NIR technologies. The non-destructive and non-invasive nature of measurements makes NIR a powerful tool in characterization of pharmaceutical solids. These benefits among others often make NIR advantageous over traditional analytical methods. However, in addition to NIR, a wide variety of other tools are naturally also available for analysis in pharmaceutical development and manufacturing, and those can often be more suitable for a given application. The versatility and rapidness of NIR will ensure its contribution to increased process understanding, better process control and improved quality of drug products. This review concentrates on the use of NIR spectroscopy from a process research perspective and highlights recent applications in the field.

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Author information

Author/s: Räsänen, Eetu (E); Sandler, Niklas (N);

Affiliation: Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Finland.

Journal and publication information

Publication Type: Journal Article; Review

Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol), published in England. (Language: eng)

Reference: 2007-Feb; vol 59 (issue 2) : pp 147-59

Dates: Created 2007/02/02; Completed 2007/05/18;

PMID: 17270069, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Dosage Forms
Drug Compounding - standards
Drug Design

Associated Chemicals: Dosage Forms (0)

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