Research article summary (published 8 Jan 2007):

Exploratory activity, motor coordination, and spatial learning in Mchr1 knockout mice.

Full Abstract

Male mice with a null mutation of Mchr1, encoding melanin concentrating hormone receptor-1, were compared to wild-type on two background strains. Mchr1 knockout (KO) mice were more active than 129/SvEv and C57BL/6J wild-type strains in a photocell actimeter. In addition, Mchr1 KO mice on the C57BL/6J background were less anxious in the elevated plus-maze, while on the 129/SvEv background, the mutants were less emotionally reactive as estimated by fecal boli and handling-related vocalization. There was no detrimental impact of the null mutation on motor coordination and spatial learning. Mchr1 KO mice had shorter latencies before reaching the escape platform, but only on the 129/SvEv background. Null mutants were lighter than C57BL/6J controls but heavier than 129/SvEv controls, attributable to interactions with strain-dependent genes.

Author information

Author/s: Lalonde, R (R); Qian, S (S);

Affiliation: Université de Rouen, Faculté de Médecine et de Pharmacie, 22 bld Gambetta, Bâtiment de Recherche, INSERM U614, IFRMP, 76183 Rouen Cedex, France. robert.lalonde(-atsign-)univ-rouen.fr

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Behavioural brain research (Behav Brain Res), published in Netherlands. (Language: eng)

Reference: 2007-Mar; vol 178 (issue 2) : pp 293-304

Dates: Created 2007/03/09; Completed 2007/05/21;

PMID: 17270288, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Analysis of Variance Animals Anxiety - genetics; metabolism Exploratory Behavior - physiology Male Mice Mice, Inbred C57BL

Mice, Inbred C57BL Mice, Knockout Motor Activity - physiology Receptors, Somatostatin - genetics; metabolism Rotarod Performance Test Species Specificity Statistics, Nonparametric

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Mch1r protein, mouse (0) ; Receptors, Somatostatin (0)

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