Impact of prenatal cocaine exposure on child behavior problems through school age.

Full Abstract

OBJECTIVE:
We examined the trajectory of childhood behavior problems after prenatal cocaine exposure.

METHODS:
The Maternal Lifestyle Study, a longitudinal cohort study, enrolled children between 1993 and 1995 at 4 centers. Prenatal cocaine exposure was determined from mothers who admitted use and/or meconium results. Exposed children were matched with a group of nonexposed children within site and by gestational age, gender, race, and ethnicity. The study began at the 1-month corrected age with a total of 1388 children enrolled. A total of 1056 were assessed for internalizing, externalizing, and total behavior problems at ages 3, 5, and 7 years using the Child Behavior Checklist. Longitudinal hierarchical linear models were used to determine the effect of prenatal cocaine exposure on behavior problem trajectories while controlling for other prenatal exposures; time-varying covariates, including ongoing caregiver use of legal and illegal substances; demographic factors; family violence; and caregiver psychological distress.

RESULTS:
High prenatal cocaine exposure was associated with the trajectory of internalizing, externalizing, and total behavior problems; these effects were independent of and less than the significant combined effect of prenatal and postnatal tobacco and alcohol exposures. Caregiver depression and family violence had independent negative influence on all behavior outcomes.

CONCLUSIONS:
Prenatal cocaine exposure has a negative impact on the trajectories of childhood behavior outcomes. When they co-occur with prenatal cocaine exposure, prenatal and postnatal tobacco and alcohol exposures have added negative effects on behavior outcomes.

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Author information

Author/s: Bada, Henrietta S (HS); Das, Abhik (A); Bauer, Charles R (CR); Shankaran, Seetha (S); Lester, Barry (B); LaGasse, Linda (L); Hammond, Jane (J); Wright, Linda L (LL); Higgins, Rosemary (R);

Affiliation: Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky, USA. hbada2(-atsign-)uky.edu

Grants: N01-HD-2-3159 (Agency:NICHD NIH HHS) ; U01 HD 36790 (Agency:NICHD NIH HHS) ; U10 HD 21385 (Agency:NICHD NIH HHS) ; U10 HD 21397 (Agency:NICHD NIH HHS) ; U10 HD 21415 (Agency:NICHD NIH HHS) ; U10 HD 27904 (Agency:NICHD NIH HHS)

Journal and publication information

Publication Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural

Journal: Pediatrics (Pediatrics), published in United States. (Language: eng)

Reference: 2007-Feb; vol 119 (issue 2) : pp e348-59

Dates: Created 2007/02/02; Completed 2007/03/19; Revised 2007/12/03;

PMID: 17272597, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Female
Humans
Longitudinal Studies
Male
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced

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