Neural mechanisms of evoked oscillations: stability and interaction with transient events.

Full Abstract

There is increasing evidence that early event-related potentials are a result of phase alignment of ongoing background oscillations of the electroencephalogram rather than additive amplitude modulation. Steady state visual-evoked potentials (ssVEPs) can be recorded using an intensity modulated stimulus, resulting in an evoked brain response at a known frequency, i.e. the stimulation frequency. Given this property, the ssVEP is ideally suited for examining the relationship between single-trial fluctuations in phase/amplitude and the evoked brain potential resulting from averaging across trials. To address this issue, the current study investigated the contribution of single trial power and intertrial phase locking to ssVEP generation by presenting a peripheral flicker. Further, transient stimuli were presented during flicker and at three increasing latency lags following flicker offset to examine (1) to what extent a stimulus can disturb the ssVEP oscillation and (2) how phase alignment during P1-N1-P2 time windows is affected during presence of evoked oscillations. The former assessment evaluates the stability of ssVEPs and the latter the phase alignment processes to transient stimuli under experimentally induced background oscillations. We observed that ssVEPs are a result of phase alignment rather than single trial amplitude modulation. In addition, ssVEP oscillations were not disturbed by transient stimuli. Finally, phase alignment in P1-N1-P2 time windows was distorted during and shortly after steady state stimulation. We conclude that ssVEPs represent strongly phase locked oscillations sharing the same generation mechanisms as early evoked potentials.(copyright) 2007 Wiley-Liss, Inc.

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Author information

Author/s: Moratti, Stephan (S); Clementz, Brett A (BA); Gao, Yuan (Y); Ortiz, Tomás (T); Keil, Andreas (A);

Affiliation: Center of Magnetoencephalography Dr. Perez Modrego, Facultad de Medicina, University Complutense of Madrid, Madrid, Spain. moratti(-atsign-)med.ucm.es

Grants: MH 57886 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Human brain mapping (Hum Brain Mapp), published in United States. (Language: eng)

Reference: 2007-Dec; vol 28 (issue 12) : pp 1318-33

Dates: Created 2007/11/20; Completed 2008/01/24;

PMID: 17274017, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Alpha Rhythm
Data Interpretation, Statistical
Electroencephalography
Evoked Potentials, Visual - physiology
Female
Humans
Male

Male
Middle Aged
Models, Statistical
Nerve Net - physiology
Photic Stimulation
Reaction Time - physiology
Regression Analysis
Theta Rhythm

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