fMRI analysis for motor paradigms using EMG-based designs: a validation study.

Full Abstract

The goal of the present validation study is to show that continuous surface EMG recorded simultaneously with 3T fMRI can be used to identify local brain activity related to (1) motor tasks, and to (2) muscle activity independently of a specific motor task, i.e. spontaneous (abnormal) movements. Five healthy participants performed a motor task, consisting of posture (low EMG power), and slow (medium EMG power) and fast (high EMG power) wrist flexion-extension movements. Brain activation maps derived from a conventional block design analysis (block-only design) were compared with brain activation maps derived using EMG-based regressors:
(1) using the continuous EMG power as a single regressor of interest (EMG-only design) to relate motor performance and brain activity, and (2) using EMG power variability as an additional regressor in the fMRI block design analysis to relate movement variability and brain activity (mathematically) independent of the motor task. The agreement between the identified brain areas for the block-only design and the EMG-only design was excellent for all participants. Additionally, we showed that EMG power variability correlated well with activity in brain areas known to be involved in movement modulation. These innovative EMG-fMRI analysis techniques will allow the application of novel motor paradigms. This is an important step forward in the study of both the normally functioning motor system and the pathophysiological mechanisms in movement disorders.Copyright 2007 Wiley-Liss, Inc.

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Author information

Author/s: van Rootselaar, Anne-Fleur (AF); Renken, Remco (R); de Jong, Bauke M (BM); Hoogduin, Johannes M (JM); Tijssen, Marina A J (MA); Maurits, Natasha M (NM);

Affiliation: Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies

Journal: Human brain mapping (Hum Brain Mapp), published in United States. (Language: eng)

Reference: 2007-Nov; vol 28 (issue 11) : pp 1117-27

Dates: Created 2007/10/18; Completed 2008/01/08;

PMID: 17274019, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Brain - anatomy & histology; physiology
Brain Mapping - methods
Electromyography - methods
Evoked Potentials, Motor - physiology
Female
Functional Laterality - physiology
Humans
Image Processing, Computer-Assisted - methods

Magnetic Resonance Imaging - methods
Male
Middle Aged
Motor Cortex - anatomy & histology; physiology
Movement - physiology
Muscle Contraction - physiology
Muscle, Skeletal - innervation; physiology
Psychomotor Performance - physiology
Volition - physiology

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