Research article summary (published 30 Dec 2006):

Association of low-grade inflammation with nephropathy in type 2 diabetic patients: role of elevated CRP-levels and 2 different gene-polymorphisms of proinflammatory cytokines.

Full Abstract

BACKGROUND: Chronic inflammatory processes are thought to play a key role in the development of micro- and macrovascular complications in type 2 diabetes mellitus. An association between low -grade inflammation and type 2 diabetes has been described in some studies. We assayed the association of two frequent polymorphisms in proinflammatory cytokines: the interleukin 6 G(-174)C promoter polymorphism [IL-6G(-174)C], the exon 2 interleukin receptor antagonist insertion deletion polymorphism [IL1RA]) and serum CRP levels with the prevalence of diabetic nephropathy in patients suffering from type 2 diabetes mellitus. SUBJECTS AND METHODS: A total of 141 patients with type 2 diabetes mellitus, with and without diabetic nephropathy was genotyped for the above mentioned polymorphisms: 66 with normoalbuminuria, 31 with microalbuminuria and 44 with macroalbuminuria. CRP levels were analysed by a high sensitivity - immunnephelometric assay. RESULTS: While a significant association be-tween macroalbuminuria and CRP could be observed (p<0,015), no associations were found between IL-6G(-174)C or IL1RA genotype and any stage of nephropathy. CRP-levels were similar in the 3 different IL-6G(-174)C genotypes as well as in the 2 IL1RA genotypes. CONCLUSIONS: In type 2 diabetic subjects elevated CRP levels are associated with an increased prevalence of albuminuria. The two investigated proinflammatory polymorphisms do not seem to contribute to initiation of nephropathy in type 2 diabetic patients but we cannot exclude effects of these polymorphisms on course of nephropathy.

Author information

Author/s: Abrahamian, H (H); Endler, G (G); Exner, M (M); Mauler, H (H); Raith, M (M); Endler, L (L); Rumpold, H (H); Gerdov, M (M); Mannhalter, C (C); Prager, R (R); Irsigler, K (K); Wagner, O F (OF);

Affiliation: Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School, Vienna, Austria.

Journal and publication information

Publication Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (Exp Clin Endocrinol Diabetes), published in Germany. (Language: eng)

Reference: 2007-Jan; vol 115 (issue 1) : pp 38-41

Dates: Created 2007/02/08; Completed 2007/04/05;

PMID: 17286233, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Aged C-Reactive Protein - analysis Diabetes Mellitus, Type 2 - blood; genetics Diabetic Nephropathies - blood; genetics Female Humans Inflammation - blood; genetics Inflammation Mediators - blood

Inflammation Mediators - blood Interleukin 1 Receptor Antagonist Protein - blood; genetics Interleukin-6 - blood; genetics Male Middle Aged Mutagenesis, Insertional Polymorphism, Genetic Sequence Deletion

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: IL1RN protein, human (0) ; Inflammation Mediators (0) ; Interleukin 1 Receptor Antagonist Protein (0) ; Interleukin-6 (0) ; C-Reactive Protein (9007-41-4)

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