Intra-uterine growth retardation after prenatal administration of Ginkgo biloba to rats.

Full Abstract

Ginkgo biloba is a plant used in the treatment of Alzheimer's disease, cerebrovascular insufficiency and peripheral vascular diseases that showed reproductive toxicity in vitro and in the mouse model. In this study, pregnant Wistar rats received 0, 3.5, 7 and 14mg/kgbodyweight/day of G. biloba, by gavage, from the 8th to 20th day of pregnancy. Rats were killed on the 21st day and the following parameters were evaluated:
maternal body weight; food and water intake; maternal's liver, kidney and ovary weights; resorption index; post-implantation loss; mean of live fetuses; fetuses and placenta mean weight; fetuses' liver, kidney, lung and brain weights; fetuses' external malformations. No significant alteration was observed in maternal parameters of toxicity, but the treatment with 7 and 14mg/kg/day of G. biloba caused significant decrease in the fetuses mean weights. The results indicated that G. biloba was not toxic to mothers, although it caused fetal intra-uterine growth retardation.

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Author information

Author/s: Pinto, Rafael M (RM); Fernandes, Eduardo S (ES); Reis, João E P (JE); Peters, Vera M (VM); Guerra, Martha de O (Mde O);

Affiliation: Centro de Biologia da Reprodução, Federal University of Juiz de Fora, Caixa, Postal 328, CEP 36001-970 Juiz de Fora, MG, Brazil.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Reproductive toxicology (Elmsford, N.Y.) (Reprod Toxicol), published in United States. (Language: eng)

Reference: 2007-Jun; vol 23 (issue 4) : pp 480-5

Dates: Created 2007/05/21; Completed 2007/07/13;

PMID: 17287108, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Dose-Response Relationship, Drug
Female
Fetal Growth Retardation - chemically induced; physiopathology
Fetal Weight - drug effects
Gestational Age
Ginkgo biloba

Ginkgo biloba
Liver - drug effects; embryology
Male
Plant Extracts - toxicity
Pregnancy
Rats
Rats, Wistar

Associated Chemicals: Plant Extracts (0)

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