Research article summary (published 8 Feb 2007):

Cytotoxic germacrane-type sesquiterpenes, pimarane-type diterpenes, and a naphthalene derivative from Wollastonia biflora.

Full Abstract

Phytochemical investigation of the whole plants of Wollastonia biflora led to the isolation and identification of three new germacrane-type sesquiterpenes (1-3), two new pimarane-type diterpenes (4, 5), and a new naphthalene glycoside (6), along with 11 known compounds. Their structures were characterized on the basis of spectroscopic analyses and chemical methods. Compounds 1, 2, and 3 showed significant cytotoxic activity against the growth of hepatocellular carcinoma BEL-7402 cells in vitro.

Author information

Author/s: Chen, Wenliang (W); Tang, Weidong (W); Zhang, Rujun (R); Lou, Liguang (L); Zhao, Weimin (W);

Affiliation: Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of natural products (J Nat Prod), published in United States. (Language: eng)

Reference: 2007-Apr; vol 70 (issue 4) : pp 567-70

Dates: Created 2007/04/27; Completed 2007/05/24;

PMID: 17291042, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Antineoplastic Agents, Phytogenic - chemistry; isolation & purification; pharmacology Asteraceae - chemistry Diterpenes, Abietane - chemistry; isolation & purification; pharmacology Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry; isolation & purification; pharmacology Humans

Humans Molecular Structure Naphthalenes - chemistry; isolation & purification; pharmacology Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal - chemistry Sesquiterpenes, Germacrane - chemistry; isolation & purification; pharmacology

Associated Chemicals: Antineoplastic Agents, Phytogenic (0) ; Diterpenes, Abietane (0) ; Drugs, Chinese Herbal (0) ; Naphthalenes (0) ; Sesquiterpenes, Germacrane (0) ; pimarane (0)

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