Induction of HIV-specific memory T-cell responses by topical DermaVir vaccine.

Full Abstract

In vivo antigen expression by plasmid DNA could provide a potent and cost-effective vaccine platform if its immunogenicity were improved to induce antigen-specific memory T-cell responses. To study these immune responses, we compared naked DNA vaccine with topical DermaVir formulated with the same HIV-1 (Gag) DNA in the mouse model. Topical DermaVir induced HIV-specific effector memory CD8(+) T-cell responses, which were 2.4-fold higher than those elicited by intramuscular injection of naked DNA. DermaVir, but not naked DNA vaccination, induced robust HIV-specific central memory T-cells responses, which are likely to be more efficient in mediating protective immunity. DermaVir formulation combined with topical administration provides an improved immunogenicity of antigen-expressing DNA vaccines.

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Author information

Author/s: Calarota, Sandra A (SA); Weiner, David B (DB); Lori, Franco (F); Lisziewicz, Julianna (J);

Affiliation: Research Institute for Genetic and Human Therapy (RIGHT), 4400 East-West Hwy, Suite 1126, Bethesda, MD 20814, USA.

Grants: R01 AI05698201 (Agency:NIAID NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Vaccine (Vaccine), published in Netherlands. (Language: eng)

Reference: 2007-Apr; vol 25 (issue 16) : pp 3070-4

Dates: Created 2007/04/02; Completed 2007/07/10; Revised 2007/12/03;

PMID: 17292518, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

AIDS Vaccines - administration & dosage; genetics; immunology
Acquired Immunodeficiency Syndrome - immunology; prevention & control
Administration, Topical
Animals
HIV Antibodies - blood
HIV-1 - genetics; immunology

Immunologic Memory
Mice
Mice, Inbred BALB C
Plasmids
T-Lymphocytes - cytology; immunology
Vaccination - methods

Associated Chemicals: AIDS Vaccines (0) ; DermaVir (0) ; HIV Antibodies (0)

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