An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus.

Full Abstract

Obesity and type 2 diabetes mellitus (T2DM) have been associated with a state of chronic low-grade inflammation. We examined the effect of exercise without weight loss on circulating inflammatory biomarkers in previously sedentary lean men and obese men with and without T2DM. Middle-aged men (8 lean, 8 obese, and 8 obese with T2DM) performed 60 minutes of aerobic exercise 5 times per week for 12 weeks without a reduction in body weight. Subjects underwent a hyperinsulinemic-euglycemic clamp before and after the 12-week exercise program to assess insulin sensitivity. Circulating interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), and C-reactive protein concentrations were measured by sandwich enzyme-linked immunosorbent assay before and after the exercise intervention. Body fat was measured using magnetic resonance imaging, and waist circumference was recorded for each subject pre- and postexercise intervention. Waist circumference and plasma IL-6 concentrations were significantly lower (P < .05) after exercise training despite no change in body weight or insulin sensitivity. There were no correlations between insulin sensitivity and IL-6. Fasting plasma PAI-1 concentration was significantly lower in the lean group compared with the obese group both pre- and postexercise intervention (P < .05). There were no changes in C-reactive protein or PAI-1 concentrations after exercise training. A 12-week exercise intervention led to reductions in waist circumference and fasting IL-6 concentrations in previously sedentary lean and obese men with or without T2DM, demonstrating significant changes in clinically relevant diabetes-related parameters despite no change in body weight.

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Author information

Author/s: Dekker, Mark J (MJ); Lee, SoJung (S); Hudson, Robert (R); Kilpatrick, Katherine (K); Graham, Terry E (TE); Ross, Robert (R); Robinson, Lindsay E (LE);

Affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Metabolism: clinical and experimental (Metabolism), published in United States. (Language: eng)

Reference: 2007-Mar; vol 56 (issue 3) : pp 332-8

Dates: Created 2007/02/12; Completed 2007/03/20;

PMID: 17292721, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adiposity
Adult
C-Reactive Protein - analysis
Diabetes Mellitus, Type 2 - blood
Exercise
Fasting
Humans

Interleukin-6 - blood
Intra-Abdominal Fat - metabolism
Male
Middle Aged
Obesity - blood
Plasminogen Activator Inhibitor 1 - blood
Weight Loss

Associated Chemicals: Interleukin-6 (0) ; Plasminogen Activator Inhibitor 1 (0) ; C-Reactive Protein (9007-41-4)

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