Ascorbic acid antagonizes nicotine-induced place preference and behavioral sensitization in mice.

Full Abstract

In the present study, the influence of ascorbic acid on the nicotine-induced behavioral sensitization and conditioned place preference was investigated in mice. In the place preference paradigm, intraperitoneal (i.p.) nicotine (1 and 1.5 mg/kg, three drug sessions) but not ascorbic acid (1, 10, 100 and 1000 mg/kg) administration induced place preference. Ascorbic acid administration (10, 100 and 1000 mg/kg, i.p.) reduced both the acquisition and expression of nicotine-induced place conditioning. Locomotor sensitization in mice was produced by intraperitoneal injection of nicotine (0.25 mg/kg) for 7 consecutive days. On the 9th day of the experiments, activity of the mice was recorded after challenge with nicotine (0.1 mg/kg, i.p.). Ascorbic acid (10, 100 and 1000 mg/kg, i.p.) was injected 20 min before each injection of nicotine (acquisition of sensitization) or acutely 20 min before a challenge nicotine injection (expression of sensitization). It was shown that ascorbic acid attenuated the acquisition of nicotine sensitization in a dose-independent manner but the expression of nicotine-induced sensitization was not affected by ascorbic acid. In conclusion, it seems that ascorbic acid may interfere with nicotine-induced place preference and behavioral sensitization in mice.

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Author information

Author/s: Sahraei, Hedayat (H); Aliabadi, Ali Akbar (AA); Zarrindast, Mohammad-Reza (MR); Ghoshooni, Hassan (H); Nasiri, Ali (A); Barzegari-Sorkheh, Amir Abbas (AA); Yari, Maryam (M); Zardooz, Homeira (H); Hossein-Mardi, Leila (L); Faraji, Nasrin (N); Shams, Jamal (J);

Affiliation: Department of Physiology and Biophysics and Behavioral Sciences Research Center (BSRC), Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran. h.Sahraei(-atsign-)bmsu.ac.ir

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: European journal of pharmacology (Eur J Pharmacol), published in Netherlands. (Language: eng)

Reference: 2007-Mar; vol 560 (issue 1) : pp 42-8

Dates: Created 2007/03/05; Completed 2007/05/15;

PMID: 17292882, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Ascorbic Acid - administration & dosage; pharmacology
Behavior, Animal - drug effects
Conditioning, Operant - drug effects
Dose-Response Relationship, Drug
Female

Injections, Intraperitoneal
Mice
Motor Activity - drug effects
Nicotine - administration & dosage; pharmacology
Nicotinic Agonists - administration & dosage; pharmacology
Vitamins - administration & dosage; pharmacology

Associated Chemicals: Nicotinic Agonists (0) ; Vitamins (0) ; Ascorbic Acid (50-81-7) ; Nicotine (54-11-5)

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