Preventive effects of Ginkgo biloba extract on ischemia-reperfusion injury in rat bladder.

Full Abstract

AIMS:
The aim of this experimental study was to evaluate the effects of Ginkgo biloba (EGb 761) on ischemia-reperfusion (I-R) injury in the rat bladder.

METHODS:
A bladder I-R injury was induced by abdominal aorta occlusion by ischemia for 30 min, followed by 45 min reperfusion in rats. The rats were divided into four groups of 7 rats each; the control, I-R, and I-R groups were pretreated intraperitoneally with 50 or 100 mg/kg G. biloba 60 min before ischemia induction. Contractile responses to carbachol through isolated organ bath studies were recorded, histological sections were evaluated by light microscopy, and TUNEL staining was performed for the evaluation of apoptosis.

RESULTS:
In the I-R group, the contractile responses of the bladder strips were lower than those of the control group (p < 0.01-0.001) and were restored by pretreatment with 100 mg/kg G. biloba (p < 0.05-0.001). Decreased polymorphonuclear leukocyte infiltration was detected in the G. biloba pretreatment groups when compared to the I-R group during histological evaluation. The ratio of TUNEL-positive nuclei was 1.84% in the I-R group, whereas it was decreased in both of the G. biloba pretreatment groups (p < 0.01, p < 0.01).

CONCLUSION:
Our data indicated that G. biloba has a preventive effect on I-R injury in rat urinary bladder.2007 S. Karger AG, Basel

Learn Faster Today Improve your study skills

Author information

Author/s: Yenilmez, Aydin (A); Kilic, Fatma Sultan (FS); Sirmagul, Basar (B); Isikli, Burhanettin (B); Aral, Erinc (E); Oner, Setenay (S);

Affiliation: Department of Urology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey. aydinyenilmez(-atsign-)yahoo.com

Journal and publication information

Publication Type: Journal Article

Journal: Urologia internationalis (Urol Int), published in Switzerland. (Language: eng)

Reference: 2007-; vol 78 (issue 2) : pp 167-72

Dates: Created 2007/02/12; Completed 2007/04/26;

PMID: 17293659, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Cardiovascular Agents - therapeutic use
Ginkgo biloba
Male
Muscle Contraction

Plant Extracts - therapeutic use
Rats
Rats, Wistar
Reperfusion Injury - prevention & control
Urinary Bladder - blood supply

Associated Chemicals: Cardiovascular Agents (0) ; Ginkgo biloba extract 761 (0) ; Plant Extracts (0)

These are the highest related articles currently in the database:

See 100+ related articles.