Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T.

Full Abstract

OBJECTIVES:
To assess the presence of perfusion abnormalities in the deep gray matter of patients with relapsing-remitting and primary progressive multiple sclerosis (MS) in comparison with healthy controls and to investigate the impact of perfusion impairment on clinical disability and fatigue.

DESIGN:
Survey.

SETTING:
Research-oriented hospital. Patients Twenty-two patients with MS and 11 age- and sex-matched healthy volunteers. Intervention Absolute cerebral blood flow, cerebral blood volume, and mean transit time were measured in the thalamus, putamen, and caudate nuclei.

MAIN OUTCOME MEASURES:
Decrease of cerebral blood flow in the deep gray matter of patients with MS and correlation between perfusion impairment and the severity of fatigue.

RESULTS:
The cerebral blood flow value averaged over the thalamus, putamen, and caudate nuclei was significantly lower in patients with primary progressive MS (P<.001) and in patients with relapsing-remitting MS (P = .01) compared with controls, and there was a trend for patients with primary progressive MS to have lower average cerebral blood flow than patients with relapsing-remitting MS (P = .06). With respect to cerebral blood volume, there was a significant difference between patients with primary progressive MS and controls (P<.001) and between the 2 groups of patients (P = .03) but not between patients with relapsing-remitting MS and controls (P>.30). The fatigue score was significantly correlated with cerebral blood flow (r = 0.4; P<.001) and cerebral blood volume (r = 0.5; P = .004).

CONCLUSION:
The decrease of tissue perfusion in the deep gray matter of patients with MS is associated with the severity of fatigue.

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Author information

Author/s: Inglese, Matilde (M); Park, Sun-Jung (SJ); Johnson, Glyn (G); Babb, James S (JS); Miles, Laura (L); Jaggi, Hina (H); Herbert, Joseph (J); Grossman, Robert I (RI);

Affiliation: Departments of Radiology and Neurology, Hospital for Joint Disease, New York University School of Medicine, 650 First Avenue, New York, NY 10016, USA. matilde.inglese(-atsign-)med.nyu.edu

Grants: R01 NS 051623 (Agency:NINDS NIH HHS) ; R37 NS 29029 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Archives of neurology (Arch Neurol), published in United States. (Language: eng)

Reference: 2007-Feb; vol 64 (issue 2) : pp 196-202

Dates: Created 2007/02/13; Completed 2007/03/13; Revised 2007/12/03;

PMID: 17296835, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Female
Humans
Image Processing, Computer-Assisted - methods
Linear Models
Magnetic Resonance Angiography
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive - physiopathology
Multiple Sclerosis, Relapsing-Remitting - physiopathology

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